膽汁酸 藥物吸收

Increased intestinal bile acid reabsorption and reduced intestinal bile acid efflux may result in increased intestinal bile acid content and total bile acid pool size in DKO mice.

精選增加的腸膽汁酸重吸收和減少的腸膽汁酸流出可能導致DKO小鼠中腸膽汁酸含量和總膽汁酸池大小增加。

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• 結(jié)果來源論著2019IF 14.7Hepatology

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Excessive production of some bile acids and bile acid malabsorption can lead to overabundance of bile acids, which is a hallmark of IBD, although the exact mechanisms remain unknown.

精選一些膽汁酸的過量產(chǎn)生和膽汁酸吸收不良可導致膽汁酸過量，這是IBD的標志，盡管確切的機制仍然未知。

• 結(jié)果來源論著2019IF 30.8Nature Methods

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Treatment with bile acid binding medications is effective in patients with bile-acid malabsorption but can also be effective in patients without bile-acid malabsorption.

膽汁酸結(jié)合藥物治療對膽汁酸吸收不良的患者有效，但對無膽汁酸吸收不良的患者也有效。

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• 引言來源論著2012IF 3.7World Journal of Gastroenterology

Bile acid binding agents may impair the absorption of some co-medications.

膽汁酸結(jié)合劑可損害一些輔助藥物的吸收。

• 所在語境

• 結(jié)果來源綜述2016IF 3.7World Journal of Gastroenterology

Recent data showed bile acids were involved in the solubilization and absorption of lipophilic drugs.

最近的數(shù)據(jù)顯示膽汁酸參與親脂性藥物的溶解和吸收。

• 所在語境

• 結(jié)果來源綜述2018IF 7.7British Journal of Pharmacology

"語境"功能：原文中本句所處在的段落的情況，通過"語境"功能，能更好理解本句的前后文和使用語境。（備注: 如果語境中只出現(xiàn)了本句，說明本句在原文中自成一小段。）

標題Secondary effects of drugs on the gut microbiome

Studies have found a correlation between the reduced levels of SCFAs in the proximal to distal colon with the corresponding increase in pH from the caecum to rectum.

研究發(fā)現(xiàn)，近端至遠端結(jié)腸中的scfa水平降低與盲腸至直腸的pH相應增加之間存在相關性。

Cefoperazone, vancomycin and clindamycin were identified as antibiotics associated with changes in the gut microbiota composition and caused decreased levels of secondary bile acids precipitating the growth and spore germination of C.?difficile.

頭孢哌酮、萬古霉素和克林霉素被鑒定為與腸道微生物群組成的變化相關的抗生素，并導致沉淀艱難梭菌生長和孢子萌發(fā)的次級膽汁酸水平降低。

Drug treatment can, however, alter the gut microbiota production of bile salts, which may subsequently affect the absorption and metabolism of co‐administered medication.

然而，藥物治療可以改變膽汁鹽的腸道菌群產(chǎn)生，這可能隨后影響共同施用藥物的吸收和代謝。

The liver is continually exposed to gut microbiota‐derived metabolites, including secondary bile acids and short chain fatty acids (SCFAs), as it receives an estimated 70% of its blood supply from the intestine.

肝臟持續(xù)暴露于腸道微生物衍生的代謝物，包括次級膽汁酸和短鏈脂肪酸 (SCFAs)，因為它從腸道接收估計70% 的血液供應。

Recent data showed bile acids were involved in the solubilization and absorption of lipophilic drugs.

本句最近的數(shù)據(jù)顯示膽汁酸參與親脂性藥物的溶解和吸收。

Drug‐induced changes in the production of SCFAs could thus indirectly alter GI pH, which as mentioned previously may precipitate changes in the microbiome.

藥物誘導的SCFAs產(chǎn)生的變化因此可以間接改變GI pH，如前所述，這可能會導致微生物組的變化。

For example, increased levels of SCFAs were linked with metformin, which could instigate the microbiota modifications associated with this drug.

例如，增加的scfa水平與二甲雙胍相關，其可引發(fā)與該藥物相關的微生物群修飾。

This is the major mechanism of bile acid re-absorption feedback inhibition of bile acid synthesis.

這是膽汁酸重吸收反饋抑制膽汁酸合成的主要機制。

• 所在語境

• 結(jié)果來源綜述2016IF 3.7World Journal of Gastroenterology

Bile acid sequestrants, another class of cholesterol-lowering drugs, also inhibit cholesterol absorption, as well as bile acid reabsorption.

膽汁酸螯合劑，另一類降膽固醇藥物，也抑制膽固醇吸收，以及膽汁酸重吸收。

• 所在語境

• 引言來源論著2013IF 5.0Faseb Journal

Intestinal bile acid absorption was increased and accompanied by increases in plasma bile acid levels, biliary bile acid secretion and enterohepatic cycling of bile acids.

腸膽汁酸吸收增加，并伴隨著血漿膽汁酸水平、膽汁膽汁酸分泌和膽汁酸的腸肝循環(huán)的增加。

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• 摘要來源論著2015IF 20.6Journal of Hepatology

These resins bind bile acids in the intestinal lumen and consequently impair bile acid resorption, thus interrupting the enterohepatic circulation of bile acids.

這些樹脂在腸腔中結(jié)合膽汁酸并因此損害膽汁酸再吸收，從而中斷膽汁酸的腸肝循環(huán)。

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• 結(jié)果來源綜述2013IF 21.6Cell Metabolism

The human ileal bile acid transporter, also known as hASBT (SLC10A2), is a key component in the enterohepatic recirculation of bile acids and serves as a target to enhance oral drug absorption.

人回腸膽汁酸轉(zhuǎn)運蛋白，也稱為hASBT (SLC10A2)，是膽汁酸腸肝再循環(huán)的關鍵組分，并作為增強口服藥物吸收的靶標。

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• 討論來源論著2006IF 4.3Molecular Pharmaceutics

Fig. 7. GG elevates plasma bile acid levels likely by promoting bile acid reabsorption.

圖7. GG可能通過促進膽汁酸重吸收來提高血漿膽汁酸水平。

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• 圖注來源論著2017IF 4.5Journal of Lipid Research

Intestinal bile acids can be absorbed by bile acid binding resin (BAR) and likely improve obesity and metabolic disorders.

腸膽汁酸可以被膽汁酸結(jié)合樹脂 (BAR)?吸收，并可能改善肥胖和代謝紊亂。

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• 結(jié)果來源綜述2018IF 3.3Journal of Immunology Research

While absorption of bile acids in proximal small intestine does not result in alterations in faecal bile acid excretion, overall pool size (figure 4a), BW and plasma triglyceride or cholesterol levels, our data show that proximal absorption of bile acids results in TBMC enrichment of the bile acid pool (figure 4b).

雖然近端小腸吸收膽汁酸不會導致糞便膽汁酸排泄、總膽汁酸池大小 (圖4a) 、BW和血漿甘油三酯或膽固醇水平的改變，但我們的數(shù)據(jù)顯示，膽汁酸的近端吸收導致膽汁酸池的TBMC富集 (圖4b)。

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• 討論來源論著2010IF 19.8Gut

Figure 1. The enterohepatic circulation of bile acids.?The various steps in bile acid synthesis, secretion, absorption and resecretion are indicated.

圖1.膽汁酸的腸肝循環(huán)。說明膽汁酸合成、分泌、吸收和再吸收的各個步驟。

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• 圖注來源論著2010IF 3.5Therapeutic Advances in Gastroenterology

This review provides in-depth insight into the mechanisms of drug absorption enhancement mediated by bile acids, but also into the molecular interactions between drugs and bile acids that can impact absorption and pharmacokinetic properties of drug molecules.

本綜述深入探討了膽汁酸介導的藥物吸收增強機制，也深入探討了藥物與膽汁酸之間的分子相互作用，這些相互作用會影響藥物分子的吸收和藥代動力學性質(zhì)。

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• 討論來源綜述2018IF 4.2Frontiers in Pharmacology

Bile acid sequestrants bind bile acids in the intestine to prevent bile acid reabsorption, thus reducing the bile acid pool size.

膽汁酸螯合劑在腸道內(nèi)結(jié)合膽汁酸，阻止膽汁酸重吸收，從而減小膽汁酸池大小。

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• 結(jié)果來源綜述2019IF 3.1Diabetes & Metabolism Journal

This transporter may also be employed as a prodrug target for enhancing oral drug bioavailability of poorly permeating compounds, where drug is conjugated to bile acid and bile acid allows for the conjugate to be taken up by ASBT.

該轉(zhuǎn)運蛋白也可用作前藥靶標，用于增強低滲透性化合物的口服藥物生物利用度，其中藥物與膽汁酸綴合，并且膽汁酸允許綴合物被ASBT吸收。

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• 引言來源論著2010IF 4.0Bioconjugate Chemistry

An alternative strategy to providing supplemental bile acids is to inhibit reabsorption of native bile acids in the terminal ileum.

提供補充膽汁酸的替代策略是抑制末端回腸中天然膽汁酸的重吸收。

• 所在語境

• 結(jié)果來源綜述2014IF 3.0Journal of Neurogastroenterology and Motility

After intestinal reabsorption, bile acids enter enterohepatic circulation, with up to 15 circulations per bile acid per day.

腸重吸收后，膽汁酸進入腸肝循環(huán)，每天每膽汁酸最多循環(huán)15次。

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• 引言來源論著2012IF 7.9Journal of Nuclear Medicine

Genetic knockout of Asbt in mice interrupts enterohepatic circulation of bile acids and causes bile acid malabsorption.

小鼠中Asbt的基因敲除中斷膽汁酸的腸肝循環(huán)并導致膽汁酸吸收不良。

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• 結(jié)果來源綜述2009IF 4.5Journal of Lipid Research

Bile acids or their salts form nanomicelles with fatty acids as drug carriers, which promote drug absorption.

膽汁酸或其鹽與脂肪酸作為藥物載體形成納米膠束，促進藥物吸收。

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• 引言來源論著2015IF 5.1International Journal of Nanomedicine

Bile acids are reabsorbed into enterocytes by the apical sodium-dependent bile acid transporter (Asbt).

膽汁酸通過頂端鈉依賴性膽汁酸轉(zhuǎn)運蛋白 (Asbt) 被重吸收到腸細胞中。

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• 引言來源論著2016IF 3.3Toxicology and Applied Pharmacology

Ninety-five percent of bile acids are reabsorbed in the lower small intestine by the apical sodium-dependent bile acid transporter (ASBT).

95% 的膽汁酸在小腸下部被頂端鈉依賴性膽汁酸轉(zhuǎn)運蛋白 (ASBT) 重吸收。

• 所在語境

• 引言來源論著2015IF 3.9Endocrinology

The human ileal bile acid transporter, also known as hASBT (SLC10A2), is a key component in the enterohepatic recirculation of bile acids, as well as a target for enhanced oral drug absorption.

人回腸膽汁酸轉(zhuǎn)運蛋白，也稱為hASBT (SLC10A2)，是膽汁酸腸肝再循環(huán)的關鍵組分，也是增強口服藥物吸收的靶標。

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• 引言來源論著2006IF 3.2Pharmaceutical Research

Interruptions of bile flow, reduction of intestinal bile acid absorption, or defects of bile acid metabolism can induce severe disease.

膽汁流動的中斷、腸膽汁酸吸收的減少或膽汁酸代謝的缺陷可誘發(fā)嚴重的疾病。

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• 討論來源論著2010IF 4.5Journal of Lipid Research

Absorbed bile acids enter into the portal bloodstream and are rapidly taken up by hepatocytes and resecreted into bile.

被吸收的膽汁酸進入門脈血流并被肝細胞迅速吸收并重新注入膽汁。

• 所在語境

• 結(jié)果來源綜述2020IF 7.7Gut Microbes

Bile acid diarrhea results from excessive amounts of bile acids entering the colon due to hepatic overexcretion of bile acids or bile acid malabsorption in the terminal ileum.

膽汁酸腹瀉是由于末端回腸中膽汁酸的肝臟過度排泄或膽汁酸吸收不良而導致過量的膽汁酸進入結(jié)腸。

• 所在語境

• 摘要來源病例報道2018IF 3.7World Journal of Gastroenterology

Each individual bile salt has an input, either de novo synthesis for primary bile acids and alcohols or intestinal absorption for newly formed secondary bile acids.

每個單獨的膽汁鹽具有輸入，初級膽汁酸和醇的從頭合成或新形成的次級膽汁酸的腸吸收。

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• 引言來源綜述2010IF 4.5Journal of Lipid Research

Alternatively, loperamide, a drug used to reduce diarrhea, results in slower transit time and increases bile acid reabsorption, reducing primary bile acid concentrations in the feces.

或者，洛哌丁胺 (一種用于減少腹瀉的藥物) 導致更慢的轉(zhuǎn)運時間并增加膽汁酸重吸收，降低糞便中的初級膽汁酸濃度。

• 所在語境

• 討論來源論著2019IF 4.1Frontiers in Cellular and Infection Microbiology

It is possible that the high fiber content of rose hip impairs the enterohepatic circulation of bile acids by preventing their re-absorption, thereby promoting increased synthesis of bile acids from cholesterol, that is, a mechanism of action similar to that of the cholesterol-lowering drug cholestyramin.

可能玫瑰果的高纖維含量通過阻止膽汁酸的再吸收而損害膽汁酸的腸肝循環(huán)，從而促進膽固醇合成膽汁酸的增加，即類似于降膽固醇藥物膽固醇酯的作用機制。

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• 討論來源RCT2012IF 3.3European Journal of Clinical Nutrition

Plasma bile acid levels are influenced by a number of variables, including hepatic bile acid synthesis and ileal bile acid reabsorption efficiency.

血漿膽汁酸水平受許多變量的影響，包括肝膽汁酸合成和回腸膽汁酸重吸收效率。

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• 討論來源論著2011IF 17.4Gastroenterology

Ileal diseases and resections result in bile acid malabsorption due to loss of intestinal bile acid transport capacity.

回腸疾病和切除由于腸道膽汁酸轉(zhuǎn)運能力的喪失而導致膽汁酸吸收不良。

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• 引言來源論著2010IF 19.8Gut

FXR influences bile acid flux via various feedforward and feedback loops, modulating bile acid synthesis, modification, absorption and uptake.

FXR通過各種前饋和反饋回路影響膽汁酸通量，調(diào)節(jié)膽汁酸合成、修飾、吸收和攝取。

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• 結(jié)果來源綜述2012IF 55.5Nature Reviews Molecular Cell Biology

A failure to reabsorb bile acid was also suggested to be a cause of diarrhea owing to excess bile acids entering the colon.

由于過量的膽汁酸進入結(jié)腸，再吸收膽汁酸的失敗也被認為是腹瀉的原因。

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• 引言來源論著2017IF 3.0Journal of Neurogastroenterology and Motility

Thus, there is uptake of bile acids into breast tissue.

因此，膽汁酸被吸收到乳腺組織中。

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• 討論來源論著2019IF 10.1Clinical Cancer Research

Bile acid malabsorption (BAM) results in excess fecal bile acids that can cause chronic diarrhea and other colon pathology.

膽汁酸吸收不良 (BAM) 導致過量的糞便膽汁酸，其可引起慢性腹瀉和其他結(jié)腸病理。

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• 引言來源論著2013IF 3.2Pharmaceutical Research

Their capability of taking up bile acids or to express genes involved in bile acid transport and metabolism in a physiological and stable level validates the model for research in other important areas of hepatology, including drug-induced liver injury (DILI).

它們吸收膽汁酸或以生理和穩(wěn)定水平表達參與膽汁酸轉(zhuǎn)運和代謝的基因的能力驗證了該模型在肝病其他重要領域的研究，包括藥物誘導的肝損傷 (DILI)。

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• 結(jié)果來源綜述2019IF 5.1Hepatology International

Reabsorbed bile acids enter hepatic portal circulation.

重吸收的膽汁酸進入肝門循環(huán)。

• 所在語境

• 結(jié)果來源綜述2018IF 3.3Journal of Immunology Research

The decreased expression of FXR leads also to a reduction in SHP inhibition of bile acid absorption, bile acid reabsorption is increased, and excretion is reduced.

FXR表達的降低也導致SHP抑制膽汁酸吸收的減少，膽汁酸重吸收增加，排泄減少。

• 所在語境

• 圖注來源論著2014IF 5.0Faseb Journal

In the distal ileum, bile acid absorption from the lumen occurs via ASBT and bile acid efflux out of the cell via OSTα / OSTβ.

在遠端回腸中，膽汁酸通過ASBT從管腔吸收，膽汁酸通過OSTα/OSTβ 從細胞流出。

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• 結(jié)果來源綜述2018IF 4.2Frontiers in Pharmacology

Dietary fat affects bile acid metabolism, because the absorption of fat requires an increase in bile flow.

膳食脂肪影響膽汁酸代謝，因為脂肪的吸收需要增加膽汁流量。