三肽-9瓜氨酸Tripeptide-9 citrulline抗糖化抗衰多肽
INCI名稱:?Tripeptide-9 citrulline
參考名稱: dGlyage
Cas No: 951775-32-9
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三肽-9瓜氨酸（INCI名稱）是一種具有皮膚護(hù)理特性的肽，用于化妝品應(yīng)用。為了闡明其在涉及金屬離子的化學(xué)途徑中的作用機(jī)制，利用分光光度法、電化學(xué)和電泳技術(shù)研究了其絡(luò)合此類離子的能力。以Cu（II）為金屬離子得到的結(jié)果與三肽-9瓜氨酸與Cu（II）形成復(fù)合物的結(jié)果一致。循環(huán)伏安法顯示了電化學(xué)電位的顯著變化。體外電泳研究證明三肽-9瓜氨酸可以保護(hù)DNA免受芬頓反應(yīng)誘導(dǎo)的自由基降解。
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Tripeptide-9 Citrulline (INCI name) is a peptide with skin care properties, used for cosmetic applications. In order to elucidate its mechanism of action in the chemical pathways that involve metal ions, its ability to complex such ions was investigated using spectrophotometrical, electrochemical and electrophoretical techniques. The obtained results using Cu(II) as metal ion were consistent with the formation of a complex between Tripeptide-9 Citrulline andCu(II). Cyclic voltammetry revealed a significant changein the electrochemical potentials. In-vitro electrophoretic studies served as a proof of concept that Tripeptide-9 Citrullinemay protect DNA from radical degradation induced by the Fenton reaction.
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三肽-9瓜氨酸可以防止過(guò)渡金屬引發(fā)的DNA結(jié)構(gòu)變化。它螯合這種離子金屬，催化不同的反應(yīng)產(chǎn)生幾種DNA損傷。粒徑減小的錯(cuò)流體脂質(zhì)體含有四肽，因此輸送到皮膚。
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Tripeptide-9 citrulline prevents DNA structure changes triggered by transition metals.It chelates such ion metals that catalyse different reaction producing several DNA lesions.Miscrofluidised liposomes with diminished particle size contain the tetrapeptide,thus delivery to the skin is enchanced.
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