賽必妥單抗，Cibisatamab，CAS:2101242-53-7，AntibodySystem Laboratories

貨號(hào)：DHC21003

產(chǎn)品鏈接：http://www.atagenix.com/product_detail-75488.html

別名：Bispecific, CEA TCB, RG-7802, RO-6958688, CAS: 2101242-53-7

簡介：Cibisatamab (CEA-TCB) 是一種 T 細(xì)胞雙特異性抗體，與癌細(xì)胞上的癌胚抗原 (CEA) 和 T 細(xì)胞上的 CD3 結(jié)合。Cibisatamab (CEA-TCB) 對(duì)細(xì)胞表面表達(dá)中到高水平 CEA 的癌細(xì)胞系觸發(fā) T 細(xì)胞殺傷。Cibisatamab (CEA-TCB) 可用于結(jié)直腸癌研究。

產(chǎn)品品牌：Antibodysystem

通用名：Cibisatamab

純度：>95% by SDS-PAGE.

濃度：1mg/ml

Formulationicon：0.01M PBS, pH 7.4.

內(nèi)毒素：Please contact with the lab for this information.

別名：Bispecific, CEA TCB, RG-7802, RO-6958688

靶點(diǎn);物種：Human CD66e/CEA/CEACAM5 & CD3E

種類：Humanized

受體鑒定：IgG1-kappa/lambdawithdomaincrossover

CAS: 2101242-53-7

存儲(chǔ)條件：Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.等相關(guān)疾病研究。

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參考文獻(xiàn)：

Three-dimensional colon cancer organoids model the response to CEA-CD3 T-cell engagers. PMID: 35154495
CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids. PMID: 30982469
Pharmacokinetics and Pharmacodynamics of T-Cell Bispecifics in the Tumour Interstitial Fluid. PMID: 34959386
Predicting Tumor Killing and T-Cell Activation by T-Cell Bispecific Antibodies as a Function of Target Expression: Combining In Vitro Experiments with Systems Modeling. PMID: 33298591
Multi-Parameter Quantitative Imaging of Tumor Microenvironments Reveals Perivascular Immune Niches Associated With Anti-Tumor Immunity. PMID: 34421928