產(chǎn)品名稱：活性氧CFTR Inhibitor-172，CAS No. 307510-92-5

產(chǎn)地：西安

規(guī)格：1mg 5mg 10mg

純度：99%

用途：僅用于科研

狀態(tài)：固體/粉末

儲(chǔ)藏條件：冷藏-20℃

溫馨提示：僅用于科研，不能用于人體實(shí)驗(yàn)！

說明：提供使用說明，核磁圖譜，包裝，價(jià)格，產(chǎn)地，制備方法，應(yīng)用，穩(wěn)定性，溶解度，簡(jiǎn)單合成等各種信息　　

The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR).CFTR inhibitor-172 is a thiazolidinone that selectively blocks the CFTR channel (Ki = 300 nM) in a voltage-independent manner.It appears to directly modulate the gating of chloride at the channel and does not prevent elevation of cAMP or inhibit other pumps or channels.In mice, CFTR inhibitor-172 prevents cholera toxin-induced fluid secretion in the small intestine, when given by intraperitoneal injection.It slows cyst growth in animal models of polycystic kidney disease.5 As CFTR also modulates glutathione (GSH) efflux, CFTR inhibitor-172 can affect intracellular GSH concentration and reactive oxygen species balance.

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編輯：XAQYBIO HAO，2023年4月20日。