補(bǔ)體因子H（Complement Factor H）是膀胱腫瘤抗原（Bladder Tumor Antigen, BTA）的具體成分，是由尿路上皮腫瘤細(xì)胞和巨噬細(xì)胞產(chǎn)生的，不是正常表皮細(xì)胞產(chǎn)生的。補(bǔ)體因子H的產(chǎn)生賦予體內(nèi)腫瘤細(xì)胞一種選擇性生長優(yōu)勢，讓細(xì)胞逃逸宿主免疫系統(tǒng)監(jiān)視，幫助腫瘤細(xì)胞逃脫人體內(nèi)在調(diào)控避免凋亡 ?。當(dāng)尿液補(bǔ)體因子H水平較高時，提示尿路上皮腫瘤的發(fā)生。補(bǔ)體因子H可用于尿路上皮腫瘤的早期檢測和復(fù)發(fā)監(jiān)測。

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生物功能：

補(bǔ)體因子H（傳統(tǒng)習(xí)慣簡稱為BTA）在控制補(bǔ)體激活替代途徑的時候扮演關(guān)鍵的負(fù)反饋作用，這個替代補(bǔ)體途徑可以裂解外來細(xì)胞。BTA結(jié)合補(bǔ)體因子C3b后，可以抑制膜攻擊復(fù)合物的形成，從而阻止細(xì)胞裂解。BTA干擾補(bǔ)體級聯(lián)反應(yīng)，以免細(xì)胞被補(bǔ)體裂解。BTA的產(chǎn)生賦予體內(nèi)腫瘤細(xì)胞一種選擇性生長優(yōu)勢，讓細(xì)胞逃逸宿主免疫系統(tǒng)監(jiān)視 。

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臨床應(yīng)用：

1?檢測尿液補(bǔ)體因子H（BTA）水平可對尿路上皮腫瘤進(jìn)行早期鑒別和復(fù)發(fā)監(jiān)測。

2?聯(lián)合尿液補(bǔ)體因子H（BTA）和尿細(xì)胞學(xué)檢查用于膀胱癌高危人群篩查。

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艾美捷補(bǔ)體因子H抗體及相關(guān)熱門研究：

編號?名稱?規(guī)格

M099?Mouse C1q?小鼠補(bǔ)體C1q蛋白

M113?Mouse C3?小鼠補(bǔ)體C3蛋白

M114?Mouse C3b?小鼠補(bǔ)體C3b蛋白

R099?Rat C1q?大鼠補(bǔ)體C1q蛋白

R113?Rat C3?大鼠補(bǔ)體C3蛋白

R114?Rat C3b?大鼠補(bǔ)體C3b蛋白

R137?Rat Factor H?大鼠Factor H補(bǔ)體因子

Rb113?Rabbit C3?兔補(bǔ)體C3蛋白

R237?Goat Anti-Rat Factor H?山羊抗大鼠因子H抗體?1.0ml

B102?GVB++ (with Ca and Mg)*?250ml

B100?GVB++ (with Ca and Mg)*?1Liter

B103?GVB° (without Ca and Mg)*?250ml

B101?GVB° (without Ca and Mg)*?1Liter

B104?GVBE (with EDTA)*?250ml

B105?GVBE (with EDTA)*?1Liter

B110?SGVB++ (low ionic strength GVB++ w/ Sucrose)*?250ml

B111?SGVB++ (low ionic strength GVB++ w/ Sucrose)*?1Liter

B112?VBS++ (with Ca and Mg)*?250ml

B113?VBS++ (with Ca and Mg)*?1Liter

B114?VBSo (without Ca and Mg)*?250ml

B115?VBSo (without Ca and Mg)*?1Liter

B200?EA (Ab-sensitized sheep E)*?5ml@5x108/ml

B201?EA (Ab-sensitized sheep E)*?10ml@5x108/ml

B202?EA (Ab-sensitized sheep E)*?20ml@5x108/ml

B210?Es (sheep E)*?20ml@5x108/ml

B300?Er (rabbit E)*?5ml@5x108/ml

B301?Er (rabbit E)*?10ml@5x108/ml

B302?Er (rabbit E)*?20ml@5x108/ml

B400?Zymosan?10ml@1x109/ml

B106?MgEGTA?10ml@0.1M

B250?MCAR?1.0ml

Hemolysin?Hemolysin?2.0ml