S-acetyl-L-glutathione is a glutathione derivative that can increase intracellular glutathione similar to a prodrug. It can be used to replenish the depletion of reduced glutathione occurring during HIV infection and to inhibit HIV replication. However, it was found to selectively induce apoptosis in human lymphoma cells, Daudi, Raji and Jurkat cells, by depleting the intracellular glutathione level rather than increase it.

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Product Info

Cas No.?3054-47-5

Purity?≥98%

Formula?C12H19N3O7S

Formula Wt.?349.36

Chemical?Name

5-[[3-acetylsulfanyl-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-2-amino-5-oxopentanoic acid

IUPAC Name?γ-Glutamyl-S-acetylcysteinylglycine

Synonym?L-glutathione, S-acetyl

Melting Point?199-204°C (dec.)

Solubility?Soluble in hot water. Practically insoluble in cold water.

Appearance?White Powder

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艾美捷?LKT Labs?S-乙?；?L-谷胱甘肽是一種谷胱甘肽衍生物，可以增加細胞內谷胱甘肽，類似于前藥。它可用于補充HIV感染期間發(fā)生的還原型谷胱甘肽的消耗，并抑制HIV復制。然而，發(fā)現它通過消耗細胞內谷胱甘肽水平而不是增加它來選擇性地誘導人淋巴瘤細胞，Daudi，Raji和Jurkat細胞的凋亡。

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S-乙?；?L-谷胱甘肽基礎信息：

編號：A1016

cas：3054-47-5

純度：≥98%

公式：C12H19N3O7S

配方重量：349.36

化學名稱：5-[[3-乙酰硫基-1-羧甲基氨基-1-氧代丙烷-2-基]氨基]-2-氨基-5-氧代戊酸

IUPAC名稱：γ-谷氨酰-S-乙酰半胱氨酸甘氨酸

同義詞：L-谷胱甘肽，?S-乙?；?/p>

熔點：199-204°C?（十進制）

溶解度：溶于熱水。幾乎不溶于冷水。

外觀：白色粉末

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S-乙?；?L-谷胱甘肽文獻參考：

Fraternale A1, Paoletti MF, Casabianca A, et.al. Inhibition of murine AIDS by pro-glutathione (GSH) molecules. Antiviral Res. 2008 Feb;77(2):120-7. PMID: 18164447

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Locigno R1, Pincemail J, Henno A, et.al. S-acetyl-glutathione selectively induces apoptosis in human lymphoma cells through a GSH-independent mechanism. Int J Oncol. 2002 Jan;20(1):69-75. PMID: 11743644

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Galzigna L1, Rizzoli V, Schiappelli P et.al. S-acetyl- and S-phenylacetyl-glutathione as glutathione precursors in rat plasma and tissue preparations. Enzyme Protein. 1994-1995;48(2):98-104. PMID: 7581748