The Dutch mutation (E22Q) aggregates more readily than the wild-type sequence. The resulting fibrils show increased neurotoxicity.荷蘭突變(E22Q)比野生型序列更容易聚集。由此產(chǎn)生的纖維顯示神經(jīng)毒性增加。

編號(hào): 196073
中文名稱: 淀粉肽(Gln22)-Amyloid β-Protein (1-42)
英文名: (Gln22)-Amyloid β-Protein (1-42)
英文同義詞: Amyloid β-Protein (1-42) E22Q, Amyloid-beta Protein (1-42) (human), Dutch Mutation, Amyloid β-Protein (1-42) Dutch Mutation, Amyloid-beta Peptide(1-42), E22Q, (human), [Gln22]-Abeta (1-42), (human), [Gln22] - beta - Amyloid (1 - 42)
CAS號(hào): 147335-12-4
單字母: H2N-DAEFRHDSGYEVHHQKLVFFAQDVGSNKGAIIGLMVGGVVIA-OH
三字母: H2N-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Gln-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-COOH
氨基酸個(gè)數(shù): 42
分子式: C203H312N56O59S1
平均分子量: 4513.05
精確分子量: 4510.29
等電點(diǎn)(PI): 6.8
pH=7.0時(shí)的凈電荷數(shù): -0.31
平均親水性: -0.23611111111111
疏水性值: 0.21
來(lái)源: 人工化學(xué)合成，僅限科學(xué)研究使用，不得用于人體。
儲(chǔ)存條件: 負(fù)80℃至負(fù)20℃
標(biāo)簽: 淀粉樣肽(Amyloid Peptides)