聲明：本專欄主要對生命科學(xué)領(lǐng)域的一些期刊文章標題進行翻譯，所有內(nèi)容均由本人手工整理翻譯。由于本人專業(yè)為生物分析相關(guān)，其他領(lǐng)域如果出現(xiàn)翻譯錯誤請諒解。

1.Translation and natural selection of micropeptides from long non-canonical RNAs.

來自長的非經(jīng)典RNA的微肽的翻譯和自然選擇。

2.A hierarchical transcription factor cascade regulates enteroendocrine cell diversity and plasticity in Drosophila.

層次分明的轉(zhuǎn)錄因子級聯(lián)調(diào)控果蠅的腸道內(nèi)分泌細胞多樣性和可塑性。

3.MIR retrotransposons link the epigenome and the transcriptome of coding genes in acute myeloid leukemia.

MIR逆轉(zhuǎn)錄子將急性骨髓性白血病的表觀基因組和編碼基因的轉(zhuǎn)錄組聯(lián)系起來。

4.Multidimensional memory topography in the medial parietal cortex identified from neuroimaging of thousands of daily memory videos.

內(nèi)側(cè)頂葉皮層的多維記憶拓撲圖從數(shù)千個日常記憶視頻的神經(jīng)影像學(xué)中識別出來。

5.Plasma membrane flipping of Syntaxin-2 regulates its inhibitory action on insulin granule exocytosis.

Syntaxin-2的質(zhì)膜翻轉(zhuǎn)調(diào)控其對胰島素顆粒外滲的抑制作用。

6.BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling.

BRCA突變狀態(tài)塑造了胰腺癌的基質(zhì)微環(huán)境，將癌癥相關(guān)成纖維細胞中clusterin的表達與HSF1信號傳導(dǎo)聯(lián)系起來。

7.Unexpected assembly machinery for 4(3H)-quinazolinone scaffold synthesis.

4(3H)-喹唑啉酮支架合成的意想不到的組裝機制。

8.Circular RNA circBNC2 inhibits epithelial cell G2-M arrest to prevent fibrotic maladaptive repair.

環(huán)狀RNA circBNC2抑制上皮細胞G2-M停滯以防止纖維化的不良修復(fù)。

9.Deep transfer learning of cancer drug responses by integrating bulk and single-cell RNA-seq data.

通過整合大量和單細胞RNA-seq數(shù)據(jù)對癌癥藥物反應(yīng)進行深度轉(zhuǎn)移學(xué)習(xí)。

10.Sexually dimorphic estrogen sensing in skeletal stem cells controls skeletal regeneration.

骨骼干細胞中的雌性雙態(tài)感應(yīng)控制骨骼再生。

11.Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures.

胰島素受體的功能選擇性由誘導(dǎo)劑捕獲的受體結(jié)構(gòu)揭示。

12.De novo analysis of bulk RNA-seq data at spatially resolved single-cell resolution.

以空間分辨率的單細胞分辨率對大量RNA-seq數(shù)據(jù)進行從頭分析。

13.Understanding fibrosis pathogenesis via modeling macrophage-fibroblast interplay in immune-metabolic context.

通過模擬巨噬細胞-成纖維細胞在免疫-代謝背景下的相互作用了解纖維化的發(fā)病機制。

14.Mendelian randomization accounting for complex correlated horizontal pleiotropy while elucidating shared genetic etiology.

孟德爾隨機化解釋了復(fù)雜的相關(guān)水平多態(tài)性，同時闡釋了共同的遺傳病因?qū)W。

15.Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis.

通過多模態(tài)單細胞分析確定人類常染色體顯性多囊腎病的細胞復(fù)雜性。

16.Inducing forgetting of unwanted memories through subliminal reactivation.

通過潛意識的重新激活誘導(dǎo)遺忘不需要的記憶。

17.Gi/o protein-coupled receptor inhibition of beta-cell electrical excitability and insulin secretion depends on Na+/K+ ATPase activation.

Gi/o蛋白偶聯(lián)受體對β細胞電興奮性和胰島素分泌的抑制取決于Na+/K+ATP酶的激活。

18.Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation.

通過CD28與CTLA4的配體的不同販運促進了細胞對共同刺激的集體控制。

19.Cellular glycan modification by B3GAT1 broadly restricts influenza virus infection.

B3GAT1的細胞糖修飾廣泛限制了流感病毒的感染。

20.Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma.

神經(jīng)元CaMKK2促進膠質(zhì)母細胞瘤的免疫抑制和檢查點阻斷的抵抗。

21.Microfluidic space coding for multiplexed nucleic acid detection via CRISPR-Cas12a and recombinase polymerase amplification.

通過CRISPR-Cas12a和重組酶聚合酶擴增進行多重核酸檢測的微流體空間編碼。

a Brief overview of the steps involved in the subtyping process. The collected cervical cell specimen is first thermolyzed. Then, RPA is performed to amplify the nine HPV subtypes. The amplicons are subsequently tested via the CRISPR-Cas12a system on the microfluidic device, followed by fluorescence imaging to obtain the readout. b On-chip testing principles. A 30-plexed starburst-shaped chip (SS-Chip) with one central inlet connected to 30 outlets is used. The outlets are preloaded with various Cas12a/crRNAs that recognize the relevant target HPV subtype. After the on-chip assay, the fluorescent readout at specific outlets (i.e., space coding) indicates the presence of relevant HPV subtypes in the sample.

子類型化過程中涉及的步驟的簡要概述。采集的宮頸細胞標本首先進行熱解。然后，進行RPA?以擴增九種HPV?亞型。?隨后通過微流體設(shè)備上的?CRISPR-Cas12a?系統(tǒng)測試擴增子，然后進行熒光成像以獲得讀數(shù)。?b?片上測試原則。?使用一個?30?重星爆型芯片（SS?芯片），其中一個中央入口連接到?30?個出口。?這些出口預(yù)裝了識別相關(guān)目標?HPV?亞型的各種?Cas12a/crRNA。?片上檢測后，特定出口處的熒光讀數(shù)（即空間編碼）表明樣本中存在相關(guān)的?HPV?亞型。

22.Single-cell profiling reveals distinct adaptive immune hallmarks in MDA5+ dermatomyositis with therapeutic implications.

單細胞分析揭示了MDA5+皮肌炎中獨特的適應(yīng)性免疫標志，并具有治療意義。

23.Automated identification of sequence-tailored Cas9 proteins using massive metagenomic data.

利用海量元基因組學(xué)數(shù)據(jù)自動識別序列定制的Cas9蛋白。

24.Proteo-genomic characterization of virus-associated liver cancers reveals potential subtypes and therapeutic targets.

病毒相關(guān)肝癌的蛋白質(zhì)基因組學(xué)特征揭示了潛在的亞型和治療目標。

25.Integration of Hi-C with short and long-read genome sequencing reveals the structure of germline rearranged genomes.

Hi-C與短線和長線基因組測序的整合揭示了種系重排基因組的結(jié)構(gòu)。

26.Glutamyl-prolyl-tRNA synthetase 1 coordinates early endosomal anti-inflammatory AKT signaling.

谷氨酰-脯氨酰-tRNA合成酶1協(xié)調(diào)早期內(nèi)體抗炎的AKT信號傳導(dǎo)。

27.CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma.

CDK12在BRAF突變的黑色素瘤中被過度激活并成為合成致死目標。

28.Isotropic reconstruction for electron tomography with deep learning.

用深度學(xué)習(xí)進行電子斷層掃描的各向異性重建。

29.Near-atomic, non-icosahedrally averaged structure of giant virus Paramecium bursaria chlorella virus 1.

巨型病毒Paramecium bursaria chlorella virus 1的近原子、非二十面體平均結(jié)構(gòu)。

30.Analysis of anti-SARS-CoV-2 Omicron-neutralizing antibody titers in different vaccinated and unvaccinated convalescent plasma sources.

不同接種疫苗和未接種疫苗的療養(yǎng)院血漿來源中的抗SARS-CoV-2 Omicron中和抗體滴度分析。

31.Multiple sources of aerobic methane production in aquatic ecosystems include bacterial photosynthesis.

水生生態(tài)系統(tǒng)中好氧甲烷生產(chǎn)的多種來源包括細菌光合作用。

32.Genome-wide rare variant score associates with morphological subtypes of autism spectrum disorder.

全基因組的罕見變體得分與自閉癥譜系障礙的形態(tài)亞型有關(guān)。

33.Natural scene sampling reveals reliable coarse-scale orientation tuning in human V1.

自然場景采樣揭示了人類V1的可靠的粗尺度方向調(diào)諧。

34.Tracing the international arrivals of SARS-CoV-2 Omicron variants after Aotearoa New Zealand reopened its border.

追蹤新西蘭奧特亞羅亞州重新開放邊境后SARS-CoV-2 Omicron變體的國際到達情況。

35.Structural insights into light-driven anion pumping in cyanobacteria.

對藍藻中光驅(qū)動的陰離子泵的結(jié)構(gòu)見解。

36.The cell-free DNA methylome captures distinctions between localized and metastatic prostate tumors.

無細胞DNA甲基組捕捉到局部和轉(zhuǎn)移性前列腺腫瘤之間的區(qū)別。

37.Flexible hyperspectral surface plasmon resonance microscopy.

靈活的高光譜表面等離子體共振顯微鏡。

38.Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity.

在抗逆轉(zhuǎn)錄病毒療法開始時給予廣泛中和的抗HIV-1抗體可維持長期的CD8+T細胞免疫。

39.Competing instabilities reveal how to rationally design and control active crosslinked gels.

競爭不穩(wěn)定性揭示了如何合理地設(shè)計和控制活性交聯(lián)凝膠。

40.Chemical space docking enables large-scale structure-based virtual screening to discover ROCK1 kinase inhibitors.

化學(xué)空間對接使得基于結(jié)構(gòu)的大規(guī)模虛擬篩選能夠發(fā)現(xiàn)ROCK1激酶抑制劑。

41.The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection.

免疫突觸揭示了慢性HIV感染期間CD8 T細胞的反常功能。

42.Structural mechanism of SGLT1 inhibitors.

SGLT1抑制劑的結(jié)構(gòu)機制。

43.A phase I study of an adenoviral vector delivering a MUC1/CD40-ligand fusion protein in patients with advanced adenocarcinoma.

在晚期腺癌患者中傳遞MUC1/CD40配體融合蛋白的腺病毒載體的I期研究。

44.Library adaptors with integrated reference controls improve the accuracy and reliability of nanopore sequencing.

帶有集成參考控制的文庫適配器提高了納米孔測序的準確性和可靠性。

45.Multiciliated cells use filopodia to probe tissue mechanics during epithelial integration in vivo.

多纖毛細胞利用絲狀體探測體內(nèi)上皮細胞整合過程中的組織力學(xué)。

46.Natural variation of Dt2 determines branching in soybean.

Dt2的自然變異決定了大豆的分枝。

47.A doxycycline- and light-inducible Cre recombinase mouse model for optogenetic genome editing.

一種用于光遺傳基因組編輯的多西環(huán)素和光誘導(dǎo)的Cre重組酶小鼠模型。

48.A toxin-deformation dependent inhibition mechanism in the T7SS toxin-antitoxin system of Gram-positive bacteria.

革蘭氏陽性菌的T7SS毒素-抗毒素系統(tǒng)中的毒素變形依賴性抑制機制。

49.Light activation of Orange Carotenoid Protein reveals bicycle-pedal single-bond isomerization.

橙色類胡蘿卜素蛋白的光激活揭示了自行車踏板的單鍵異構(gòu)化。

50.Nutrient regulation of lipochitooligosaccharide recognition in plants via NSP1 and NSP2.

營養(yǎng)物質(zhì)通過NSP1和NSP2調(diào)控植物的脂溶性寡糖識別。

51.A slit-diaphragm-associated protein network for dynamic control of renal filtration.

用于動態(tài)控制腎臟濾過的狹縫-膈肌相關(guān)蛋白網(wǎng)絡(luò)。

52.ESRP1-regulated isoform switching of LRRFIP2 determines metastasis of gastric cancer.

ESRP1調(diào)節(jié)的LRRFIP2的異構(gòu)體轉(zhuǎn)換決定了胃癌的轉(zhuǎn)移。

53.Strain level microbial detection and quantification with applications to single cell metagenomics.

應(yīng)用于單細胞元基因組學(xué)的菌種級微生物檢測和量化。

54.Prevalence and mechanisms of evolutionary contingency in human influenza H3N2 neuraminidase.

人流感H3N2神經(jīng)氨酸酶的普遍性和進化偶然性機制。

55.Structures of the CcmABCD heme release complex at multiple states.

CcmABCD血紅素釋放復(fù)合物在多種狀態(tài)下的結(jié)構(gòu)。

56.The N6-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity.

N6-甲基腺苷甲基轉(zhuǎn)移酶METTL16通過保障基因組完整性實現(xiàn)紅細胞生成。

57.The emergence and development of behavioral individuality in clonal fish.

克隆魚行為個體性的出現(xiàn)和發(fā)展。

58.Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection.

霧化融合抑制肽保護獼猴免受麻疹病毒感染。

59.Ablation of CD8+ T cell recognition of an immunodominant epitope in SARS-CoV-2 Omicron variants BA.1, BA.2 and BA.3.

SARS-CoV-2 Omicron變體BA.1、BA.2和BA.3中CD8+T細胞對免疫優(yōu)勢表位識別的消融。

60.Dynamic HIV-1 spike motion creates vulnerability for its membrane-bound tripod to antibody attack.

動態(tài)的HIV-1尖峰運動使其膜結(jié)合的三聯(lián)體容易受到抗體的攻擊。

61.Arctic introgression and chromatin regulation facilitated rapid Qinghai-Tibet Plateau colonization by an avian predator.

北極引入和染色質(zhì)調(diào)控促進了青藏高原被一種鳥類捕食者快速殖民。

62.Small molecules targeting the disordered transactivation domain of the androgen receptor induce the formation of collapsed helical states.

靶向雄性激素受體無序轉(zhuǎn)導(dǎo)域的小分子誘導(dǎo)形成塌陷的螺旋狀態(tài)。

63.GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation.

GPR97通過PAR2激活的上游大分子復(fù)合物引發(fā)人類中性粒細胞的炎癥過程。

64.Blue and green food webs respond differently to elevation and land use.

藍色和綠色食物網(wǎng)對海拔高度和土地利用的反應(yīng)不同。

65.Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation.

上皮細胞柯薩奇病毒腺病毒受體促進屋塵螨引起的肺部炎癥。

66.Ubiquitin proteolysis of a CDK-related kinase regulates titan cell formation and virulence in the fungal pathogen Cryptococcus neoformans.

CDK相關(guān)激酶的泛素蛋白分解調(diào)控真菌病原體新隱球菌的泰坦細胞形成和毒力。

67.Endothelial alpha globin is a nitrite reductase.

內(nèi)皮細胞α球蛋白是一種亞硝酸鹽還原酶。

68.Cryo-EM structure of an ATTRwt amyloid fibril from systemic non-hereditary transthyretin amyloidosis.

來自系統(tǒng)性非遺傳性轉(zhuǎn)甲狀腺素淀粉樣變性的ATTRwt淀粉樣纖維的低溫電鏡結(jié)構(gòu)。

69.Genomic signatures associated with maintenance of genome stability and venom turnover in two parasitoid wasps.

兩種寄生蜂中與維持基因組穩(wěn)定性和毒液周轉(zhuǎn)有關(guān)的基因組特征。

70.Aversive memory formation in humans involves an amygdala-hippocampus phase code.

人類厭惡性記憶的形成涉及杏仁核-海馬體相位代碼。

71.A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.

一個獨特的哺乳動物disome碰撞界面包含了uS10的K63連接的多泛素化，以觸發(fā)hRQT介導(dǎo)的亞單位解離。

72.Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control.

人類mtRF1終止了COX1的翻譯，它的消減誘發(fā)了線粒體核糖體相關(guān)的質(zhì)量控制。

73.The oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinoma.

致癌性融合蛋白DNAJB1-PRKACA可被基于肽的免疫療法特異性地靶向于纖維化肝細胞癌。

74.Distinct organization of two cortico-cortical feedback pathways.

兩條皮層反饋通路的不同組織.

75.Targeting vasoactive intestinal peptide-mediated signaling enhances response to immune checkpoint therapy in pancreatic ductal adenocarcinoma.

靶向血管活性腸肽介導(dǎo)的信號傳遞增強了對胰腺導(dǎo)管腺癌免疫檢查點療法的反應(yīng)。

76.Divergent regulation of basement membrane trafficking by human macrophages and cancer cells.

人類巨噬細胞和癌細胞對基底膜販運的不同調(diào)節(jié)。

77.Molecular insights into DNA recognition and methylation by non-canonical type I restriction-modification systems.

對非經(jīng)典I型限制性修飾系統(tǒng)的DNA識別和甲基化的分子見解。

78.Transient inhibition of p53 enhances prime editing and cytosine base-editing efficiencies in human pluripotent stem cells.

p53的短暫抑制增強了人類多能干細胞的原基編輯和胞嘧啶堿基編輯的效率。

79.Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism.

肝臟甲狀腺激素信號通過膽汁酸介導(dǎo)的FXR拮抗作用調(diào)節(jié)GLP-1的產(chǎn)生來調(diào)節(jié)葡萄糖的穩(wěn)態(tài)。

80.Human cooperation in changing groups in a large-scale public goods game.

大規(guī)模公共產(chǎn)品游戲中人類在變化群體中的合作。

81.Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium.

心肌內(nèi)出血驅(qū)動梗塞心肌的脂肪變性。

82.Revealing β-TrCP activity dynamics in live cells with a genetically encoded biosensor.

用基因編碼的生物傳感器揭示活細胞中β-TrCP的活動動態(tài)。

83.Eya-controlled affinity between cell lineages drives tissue self-organization during Drosophila oogenesis.

細胞系之間的Eya控制的親和力驅(qū)動果蠅卵生期間的組織自組織。

84.Juxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly.

在催化有絲分裂檢查點復(fù)合體組裝過程中，Bub1和Cdc20并列在磷酸化的Mad1上。

85.V1-bypassing suppression leads to direction-specific microsaccade modulation in visual coding and perception.

V1繞行抑制導(dǎo)致視覺編碼和感知中的方向特異性微信調(diào)制。

86.Clonal somatic copy number altered driver events inform drug sensitivity in high-grade serous ovarian cancer.

克隆體細胞拷貝數(shù)改變的驅(qū)動事件為高等級漿液性卵巢癌的藥物敏感性提供了依據(jù)。

87.Crystal structure of the Na+/H+ antiporter NhaA at active pH reveals the mechanistic basis for pH sensing.

活性pH值下的Na+/H+抗體NhaA的晶體結(jié)構(gòu)揭示了pH感應(yīng)的機制基礎(chǔ)。

88.Polerovirus N-terminal readthrough domain structures reveal molecular strategies for mitigating virus transmission by aphids.

極病毒N端通讀結(jié)構(gòu)域結(jié)構(gòu)揭示了減輕蚜蟲傳播病毒的分子策略。

89.Optogenetic-controlled immunotherapeutic designer cells for post-surgical cancer immunotherapy.

光遺傳學(xué)控制的免疫治療設(shè)計細胞用于外科手術(shù)后的癌癥免疫治療。

90.Multi-omics characterization of autophagy-related molecular features for therapeutic targeting of autophagy.

自噬相關(guān)分子特征的多組學(xué)特征，用于自噬的治療靶向。

91.ΔFosB accumulation in hippocampal granule cells drives cFos pattern separation during spatial learning.

ΔFosB在海馬顆粒細胞中的積累推動了空間學(xué)習(xí)中的cFos模式分離。

92.A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringenin.

一種真菌NRPS-PKS酶催化了黃酮類化合物柚皮苷的形成。

93.Drivers of global mangrove loss and gain in social-ecological systems.

社會生態(tài)系統(tǒng)中全球紅樹林損失和收益的驅(qū)動因素。

94.The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α.

1型糖尿病基因TYK2調(diào)控β細胞發(fā)育及其對干擾素-α的反應(yīng)。

95.Ultrafast one-minute electronic detection of SARS-CoV-2 infection by 3CLpro enzymatic activity in untreated saliva samples.

未經(jīng)處理的唾液樣本中3CLpro酶活性對SARS-CoV-2感染的超快速一分鐘電子檢測。

96.Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda.

烏干達北部惡性瘧原蟲對雙氫青蒿素和魯米凡特林的敏感性下降。

97.METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.

METTL3乙?；ㄟ^微調(diào)其核和細胞膜功能阻礙了癌癥的轉(zhuǎn)移。

98.Subcellular spatial transcriptomics identifies three mechanistically different classes of localizing RNAs.

亞細胞空間轉(zhuǎn)錄組學(xué)確定了三類機制上不同的定位RNAs。

99.Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor.

G蛋白偶聯(lián)血小板活化因子受體的低聚物導(dǎo)致的偏向性信號傳遞。

100.Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome.

唐氏綜合征Ts65Dn小鼠模型中Brwd1拷貝數(shù)恢復(fù)對缺陷的拯救。

101.HiFi metagenomic sequencing enables assembly of accurate and complete genomes from human gut microbiota.

高保真元基因組測序能夠從人類腸道微生物群中組裝出準確和完整的基因組。

102.Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs.

成纖維細胞A20支配著纖維化的易感性，它被DREAM壓制會促進多個器官的纖維化。

103.Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors.

心肌TRPC6介導(dǎo)的Zn2+流入通過β-腎上腺素受體誘導(dǎo)有益的正性肌力。

104.Kynurenine promotes neonatal heart regeneration by stimulating cardiomyocyte proliferation and cardiac angiogenesis.

犬尿喹啉通過刺激心肌細胞增殖和心臟血管生成促進新生兒心臟再生。

105.Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes.

新發(fā)1型糖尿病患兒腸道微生物群的功能和代謝改變。

106.Termination of the unfolded protein response is guided by ER stress-induced HAC1 mRNA nuclear retention.

未折疊蛋白反應(yīng)的終止由ER壓力誘導(dǎo)的HAC1 mRNA核保留引導(dǎo)。

107.SUMMIT: An integrative approach for better transcriptomic data imputation improves causal gene identification.

SUMMIT：?更好的轉(zhuǎn)錄組數(shù)據(jù)歸納的綜合方法改善了因果基因的識別。

108.Subcellular localization of type IV pili regulates bacterial multicellular development.

IV型纖毛的亞細胞定位調(diào)控細菌的多細胞發(fā)育。

109.Binary-FRET reveals transient excited-state structure associated with activity-dependent CaMKII - NR2B binding and adaptation.

Binary-FRET揭示了與活動依賴的CaMKII - NR2B結(jié)合和適應(yīng)有關(guān)的瞬時興奮態(tài)結(jié)構(gòu)。

110.Common evolutionary origin of acoustic communication in choanate vertebrates.

舌尖上的脊椎動物聲音交流的共同進化起源。

111.Intestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost.

腸道特異性去除DAF-2后，優(yōu)雅動物的壽命幾乎翻倍，而健身成本很小。

112.Salience memories formed by value, novelty and aversiveness jointly shape object responses in the prefrontal cortex and basal ganglia.

由價值、新穎性和厭惡性形成的顯著性記憶共同塑造了前額葉皮層和基底神經(jīng)節(jié)中的物體反應(yīng)。

113.Cone opponent functional domains in primary visual cortex combine signals for color appearance mechanisms.

初級視覺皮層中的錐體對手功能域結(jié)合了顏色外觀機制的信號。

114.Cell-specific bioorthogonal tagging of glycoproteins.

細胞特異性生物正交標簽的糖蛋白。

115.E-cigarettes and their lone constituents induce cardiac arrhythmia and conduction defects in mice.

電子煙及其孤獨成分誘發(fā)小鼠的心律失常和傳導(dǎo)缺陷。

116.Computational pharmacogenomic screen identifies drugs that potentiate the anti-breast cancer activity of statins.

計算藥物基因組學(xué)篩選出能增強他汀類藥物抗乳腺癌活性的藥物。

117.A universal glycoenzyme biosynthesis pipeline that enables efficient cell-free remodeling of glycans.

一個通用的糖酶生物合成管道，使糖類的高效無細胞重塑。

118.Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice.

小鼠小膠質(zhì)細胞碎片被星形膠質(zhì)細胞通過C4b促進的吞噬作用清除，并通過RUBICON依賴的非典范自噬作用進行降解。

119.Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2.

轉(zhuǎn)錄因子Emx2在耳石器官中建立的雙向敏感性的功能。

120.Enhancing Gasdermin-induced tumor pyroptosis through preventing ESCRT-dependent cell membrane repair augments antitumor immune response.

通過阻止ESCRT依賴性細胞膜修復(fù)加強Gasdermin誘導(dǎo)的腫瘤熱化，增強了抗腫瘤免疫反應(yīng)。

121.Ribosome-mediated biosynthesis of pyridazinone oligomers in vitro.

體外核糖體介導(dǎo)的噠嗪酮低聚物的生物合成。

122.Purification and structural characterization of the Na+-translocating ferredoxin: NAD+ reductase (Rnf) complex of Clostridium tetanomorphum.

四面體梭菌的Na+轉(zhuǎn)運遞質(zhì)毒素：NAD+還原酶（Rnf）復(fù)合物的純化和結(jié)構(gòu)特征。

123.Engineered helicase replaces thermocycler in DNA amplification while retaining desired PCR characteristics.

工程化的螺旋酶在DNA擴增中取代了熱循環(huán)器，同時保留了理想的PCR特性。

124.Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune evasion.

通過LAT2介導(dǎo)的氨基酸攝取對CD47表達的代謝控制促進腫瘤免疫規(guī)避。

125.A noncanonical function of EIF4E limits ALDH1B1 activity and increases susceptibility to ferroptosis.

EIF4E的非經(jīng)典功能限制了ALDH1B1的活性并增加了對鐵中毒的易感性。

126.Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine.

納米顆粒疫苗誘導(dǎo)的SARS-CoV-2中和與保護的廣度。

127.Retinoblastoma protein as an intrinsic BRD4 inhibitor modulates small molecule BET inhibitor sensitivity in cancer.

視網(wǎng)膜母細胞瘤蛋白作為一種內(nèi)在的BRD4抑制劑調(diào)節(jié)癌癥中小分子BET抑制劑的敏感性。

128.Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer.

冷凍顯微鏡揭示了免疫球蛋白M五聚體中靈活鉸鏈運動的結(jié)構(gòu)基礎(chǔ)。

129.Detection and prevalence of SARS-CoV-2 co-infections during the Omicron variant circulation in France.

法國Omicron變體循環(huán)期間SARS-CoV-2合并感染的檢測和流行情況。

130.Contact tracing reveals community transmission of COVID-19 in New York City.

接觸追蹤揭示了紐約市COVID-19的社區(qū)傳播。

131.Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560.

MRK-560對presenilin-1的同種型選擇性抑制的分子基礎(chǔ)。

132.Characterization of somatic structural variations in 528 Chinese individuals with Esophageal squamous cell carcinoma.

528名中國食道鱗狀細胞癌患者的體細胞結(jié)構(gòu)變異特征。

133.Single-cell transcriptomic analysis highlights origin and pathological process of human endometrioid endometrial carcinoma.

單細胞轉(zhuǎn)錄組分析突出了人類子宮內(nèi)膜癌的起源和病理過程。

134.Epigenetic control of chromosome-associated lncRNA genes essential for replication and stability.

染色體相關(guān)lncRNA基因的表觀遺傳學(xué)控制對復(fù)制和穩(wěn)定至關(guān)重要。

135.Protein language models trained on multiple sequence alignments learn phylogenetic relationships.

基于多序列排列訓(xùn)練的蛋白質(zhì)語言模型學(xué)習(xí)系統(tǒng)發(fā)育關(guān)系。

136.REDD1 promotes obesity-induced metabolic dysfunction via atypical NF-κB activation.

REDD1通過非典型的NF-κB激活促進肥胖誘導(dǎo)的代謝功能障礙。

137.PD-L1-directed PlGF/VEGF blockade synergizes with chemotherapy by targeting CD141+ cancer-associated fibroblasts in pancreatic cancer.

PD-L1導(dǎo)向的PlGF/VEGF阻斷通過靶向胰腺癌中CD141+癌相關(guān)成纖維細胞與化療協(xié)同作用。

138.Reward salience but not spatial attention dominates the value representation in the orbitofrontal cortex.

獎勵顯著性而非空間注意主導(dǎo)了眶額皮層的價值表征。

139.Layer-specific, retinotopically-diffuse modulation in human visual cortex in response to viewing emotionally expressive faces.

人類視覺皮層對觀看情緒表達面孔的反應(yīng)具有層特異性和視網(wǎng)膜擴散性的調(diào)制。

140.TRPM8 contributes to sex dimorphism by promoting recovery of normal sensitivity in a mouse model of chronic migraine.

TRPM8通過促進慢性偏頭痛小鼠模型中正常敏感性的恢復(fù)而對性別二形性作出貢獻。

141.Ectopic expression of sericin enables efficient production of ancient silk with structural changes in silkworm.

絲膠蛋白的異位表達使家蠶高效生產(chǎn)具有結(jié)構(gòu)變化的古絲。

142.Seeing the unseen: High-resolution AFM imaging captures antibiotic action in bacterial membranes.

看不見的東西：高分辨率AFM成像捕捉到細菌膜中的抗生素作用。

143.Antibiotic polymyxin arranges lipopolysaccharide into crystalline structures to solidify the bacterial membrane.

抗生素多粘菌素將脂多糖排列成結(jié)晶結(jié)構(gòu)，使細菌膜凝固。

144.The influenza virus PB2 protein evades antiviral innate immunity by inhibiting JAK1/STAT signalling.

流感病毒PB2蛋白通過抑制JAK1/STAT信號來逃避抗病毒的先天免疫。

145.Functional architecture of executive control and associated event-related potentials in macaques.

獼猴執(zhí)行控制和相關(guān)事件相關(guān)電位的功能結(jié)構(gòu)。

146.Global mapping of GalNAc-T isoform-specificities and O-glycosylation site-occupancy in a tissue-forming human cell line.

形成組織的人類細胞系中GalNAc-T異構(gòu)體特異性和O-糖基化位點占用的全球圖譜。

147.Priming conditions shape breadth of neutralizing antibody responses to sarbecoviruses.

刺激條件決定了對沙貝科病毒的中和抗體反應(yīng)的廣度。

148.Population genomics of Puccinia graminis f.sp. tritici highlights the role of admixture in the origin of virulent wheat rust races.

小麥銹病菌（Puccinia graminis f.sp. tritici）的群體基因組學(xué)強調(diào)了混雜在有毒的小麥銹病種族起源中的作用。

149.Micro-scale functional modules in the human temporal lobe.

人類顳葉的微觀尺度功能模塊。

150.Translational reprogramming in response to accumulating stressors ensures critical threshold levels of Hsp90 for mammalian life.

應(yīng)對累積壓力的翻譯重編程確保了Hsp90對哺乳動物生命的關(guān)鍵閾值水平。

151.Investigating lytic polysaccharide monooxygenase-assisted wood cell wall degradation with microsensors.

用微型傳感器研究多糖單氧酶輔助的木材細胞壁降解。

152.Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice.

獎勵和厭惡處理由輸入定義的小鼠平行的阿肯色腦核回路進行。

153.Molecular insights into the distinct signaling duration for the peptide-induced PTH1R activation.

對肽誘導(dǎo)的PTH1R激活的不同信號時間的分子見解。

154.Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment.

嗜鉻細胞瘤和副神經(jīng)節(jié)瘤的單核和批量組織基因表達分析將疾病亞型與腫瘤微環(huán)境聯(lián)系起來。

155.The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics.

膽固醇運輸?shù)鞍譍RAMD1C調(diào)控自噬啟動和線粒體生物能量學(xué)。

156.Wnt4 is heterogeneously activated in maturing β-cells to control calcium signaling, metabolism and function.

Wnt4在成熟的β細胞中被異質(zhì)性激活，控制鈣信號、代謝和功能。

157.The retaining β-Kdo glycosyltransferase WbbB uses a double-displacement mechanism with an intermediate adduct rearrangement step.

保留的β-Kdo糖基轉(zhuǎn)移酶WbbB使用一個具有中間加合物重排步驟的雙置換機制。

158.Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model.

神經(jīng)元-胃細胞集合體tauopathy模型的單細胞轉(zhuǎn)錄組分析。

159.Incorporating evolutionary and threat processes into crop wild relatives conservation.

將進化和威脅過程納入農(nóng)作物野生近緣植物保護中。

160.Transcriptome-wide and stratified genomic structural equation modeling identify neurobiological pathways shared across diverse cognitive traits.

全轉(zhuǎn)錄組和分層基因組結(jié)構(gòu)方程模型確定了不同認知特征中共享的神經(jīng)生物學(xué)途徑。

161.Splicing factor BUD31 promotes ovarian cancer progression through sustaining the expression of anti-apoptotic BCL2L12.

拼接因子BUD31通過維持抗凋亡性BCL2L12的表達促進卵巢癌的進展。

162.CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro.

CRISPR/Cas9介導(dǎo)的切除C9ORF72中導(dǎo)致ALS/FTD的六核苷酸重復(fù)擴增，在體內(nèi)和體外挽救了主要疾病機制。

163.Sleep decreases neuronal activity control of microglial dynamics in mice.

睡眠降低了小鼠小膠質(zhì)細胞動態(tài)的神經(jīng)元活動控制。

164.WASH activation controls endosomal recycling and EGFR and Hippo signaling during tumor-suppressive cell competition.

WASH的激活控制了腫瘤抑制細胞競爭過程中的內(nèi)體回收和EGFR及Hippo信號的傳遞。

165.Long-term whole blood DNA preservation by cost-efficient cryosilicification.

通過具有成本效益的冷凍保存全血DNA。

166.DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon.

DNA甲基轉(zhuǎn)移酶3A控制結(jié)腸上皮屏障功能和再生。

167.Cross-linking of the endolysosomal system reveals potential flotillin structures and cargo.

內(nèi)溶酶體系統(tǒng)的交聯(lián)揭示了潛在的弗羅提林結(jié)構(gòu)和貨物。

168.Blood monocyte-derived CD169+ macrophages contribute to antitumor immunity against glioblastoma.

血液中單核細胞衍生的CD169+巨噬細胞對膠質(zhì)母細胞瘤的抗腫瘤免疫有貢獻。

169.Promiscuity of response regulators for thioredoxin steers bacterial virulence.

硫氧還蛋白反應(yīng)調(diào)節(jié)器的普適性引導(dǎo)了細菌的毒力。

170.Combining mass spectrometry and machine learning to discover bioactive peptides.

結(jié)合質(zhì)譜法和機器學(xué)習(xí)發(fā)現(xiàn)生物活性肽。

171.Rapid antibiotic susceptibility testing and species identification for mixed samples.

混合樣品的快速抗生素藥敏試驗和物種鑒定。

172.Atomic resolution protein allostery from the multi-state structure of a PDZ domain.

從一個PDZ結(jié)構(gòu)域的多態(tài)結(jié)構(gòu)看原子分辨率的蛋白質(zhì)異構(gòu)。

173.Genomic insights into the physiology of Quinella, an iconic uncultured rumen bacterium.

從基因組學(xué)角度深入了解昆侖菌--一種標志性的未培養(yǎng)的瘤胃細菌的生理學(xué)。

174.Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression.

腫瘤產(chǎn)生的和衰老相關(guān)的副代謝物甲基丙二酸促進了癌癥相關(guān)的成纖維細胞的激活以推動轉(zhuǎn)移性進展。

175.A BDNF-TrkB autocrine loop enhances senescent cell viability.

BDNF-TrkB自分泌回路增強了衰老細胞的活力。

176.Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor.

對芳烴受體配體結(jié)合機制的結(jié)構(gòu)深入研究。

177.Central role of Prominin-1 in lipid rafts during liver regeneration.

肝臟再生過程中Prominin-1在脂質(zhì)筏中的核心作用。

178.Systems-biology analysis of rheumatoid arthritis fibroblast-like synoviocytes implicates cell line-specific transcription factor function.

類風(fēng)濕性關(guān)節(jié)炎成纖維細胞樣滑膜細胞的系統(tǒng)生物學(xué)分析暗示了細胞系特異性轉(zhuǎn)錄因子的功能。

179.Cryo-EM structures of thermostabilized prestin provide mechanistic insights underlying outer hair cell electromotility.

熱穩(wěn)定的prestin的低溫電鏡結(jié)構(gòu)提供了關(guān)于外毛細胞電動性的機械學(xué)見解。

180.Hemisphere-specific spatial representation by hippocampal granule cells.

海馬顆粒細胞的半球特異性空間表示。

181.Acute deletion of TET enzymes results in aneuploidy in mouse embryonic stem cells through decreased expression of Khdc3.

TET酶的急性缺失通過Khdc3的表達減少導(dǎo)致小鼠胚胎干細胞的非整倍體。

182.p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition.

正常食道中的p53突變會促進多個階段的癌變，但會受到克隆競爭的制約。

183.Synthetic biology-instructed transdermal microneedle patch for traceable photodynamic therapy.

合成生物學(xué)結(jié)構(gòu)的透皮微針貼片用于可追蹤的光動力療法。

184.RNA G-quadruplex structure contributes to cold adaptation in plants.

RNA G-四聯(lián)體結(jié)構(gòu)有助于植物的冷適應(yīng)。

185.Proteogenomics refines the molecular classification of chronic lymphocytic leukemia.

蛋白質(zhì)基因組學(xué)完善了慢性淋巴細胞白血病的分子分類。

186.Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape.

原發(fā)性人類淋巴瘤B細胞的病毒轉(zhuǎn)導(dǎo)揭示了NOTCH介導(dǎo)的免疫逃避機制。

187.NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart.

NIMA相關(guān)激酶9調(diào)節(jié)心臟中重要肌球蛋白輕鏈的磷酸化。

188.Cryogenic contrast-enhanced microCT enables nondestructive 3D quantitative histopathology of soft biological tissues.

低溫造影劑增強的微型CT實現(xiàn)了軟體生物組織的無損三維定量組織病理學(xué)研究。

189.Harnessing bioengineered microbes as a versatile platform for space nutrition.

利用生物工程微生物作為空間營養(yǎng)的多功能平臺。

190.Sublinear scaling of the cellular proteome with ploidy.

細胞蛋白質(zhì)組與倍體的亞線性比例。

191.The genome and lifestage-specific transcriptomes of a plant-parasitic nematode and its host reveal susceptibility genes involved in trans-kingdom synthesis of vitamin B5.

一種植物寄生線蟲及其宿主的基因組和生命期特定的轉(zhuǎn)錄組揭示了參與維生素B5跨王國合成的易感基因。

192.CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase.

催化活性酶丙酮酸羧化酶的低溫EM結(jié)構(gòu)探索。

193.Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor.

金屬蛋白酶meprinα與小分子抑制劑復(fù)合物的螺旋狀超微結(jié)構(gòu)。

194.Molecular architecture of the glycogen- committed PP1/PTG holoenzyme.

糖原承諾的PP1/PTG全能酶的分子結(jié)構(gòu)。

195.Immature olfactory sensory neurons provide behaviourally relevant sensory input to the olfactory bulb.

未成熟的嗅覺神經(jīng)元向嗅球提供行為上相關(guān)的感覺輸入。

196.The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans.

未折疊蛋白反應(yīng)逆轉(zhuǎn)了葡萄糖對化學(xué)滅菌的優(yōu)雅動物壽命的影響。

197.Remodelling of tumour microenvironment by microwave ablation potentiates immunotherapy of AXL-specific CAR T cells against non-small cell lung cancer.

微波消融對腫瘤微環(huán)境的重塑增強了AXL特異性CAR T細胞對非小細胞肺癌的免疫治療。

198.Suppression of heterotopic ossification in fibrodysplasia ossificans progressiva using AAV gene delivery.

利用AAV基因遞送抑制纖維發(fā)育不良骨質(zhì)增生癥的異位骨化。

199.Engineered cell differentiation and sexual reproduction in probiotic and mating yeasts.

益生菌和交配酵母的工程化細胞分化和有性繁殖。

200.Brainstem networks construct threat probability and prediction error from neuronal building blocks.

腦干網(wǎng)絡(luò)從神經(jīng)元構(gòu)建塊中構(gòu)建威脅概率和預(yù)測誤差。

201.P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells.

P300通過調(diào)節(jié)輻射誘導(dǎo)的膠質(zhì)瘤干細胞向血管樣細胞轉(zhuǎn)化促進腫瘤復(fù)發(fā)。

202.Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota.

與先天免疫、環(huán)境感應(yīng)和細胞功能有關(guān)的宿主遺傳因子與人類皮膚微生物群有關(guān)。

203.Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development.

Runx2和Runx3在手術(shù)誘導(dǎo)的骨關(guān)節(jié)炎發(fā)展過程中對關(guān)節(jié)軟骨細胞有不同的調(diào)節(jié)作用。

204.HBEGF-TNF induce a complex outer retinal pathology with photoreceptor cell extrusion in human organoids.

HBEGF-TNF在人類器官中誘發(fā)復(fù)雜的外視網(wǎng)膜病變與光感受器細胞擠壓。

205.Systematic design of cell membrane coating to improve tumor targeting of nanoparticles.

系統(tǒng)設(shè)計細胞膜涂層以提高納米粒子的腫瘤靶向性.

206.Proteome effects of genome-wide single gene perturbations.

全基因組單基因擾動的蛋白質(zhì)組效應(yīng)。

207.Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts.

Tmem65對小鼠心臟夾層盤的結(jié)構(gòu)和功能至關(guān)重要。

208.A simple thermodynamic description of phase separation of Nup98 FG domains.

Nup98 FG結(jié)構(gòu)域的相分離的簡單熱力學(xué)描述。

209.Selective macrocyclic peptide modulators of Lys63-linked ubiquitin chains disrupt DNA damage repair.

Lys63連接的泛素鏈的選擇性大環(huán)肽調(diào)節(jié)劑破壞了DNA損傷修復(fù)。

210.The hypoxia response pathway promotes PEP carboxykinase and gluconeogenesis in C. elegans.

低氧反應(yīng)途徑促進優(yōu)雅動物的PEP羧基激酶和葡萄糖生成。

211.Effect of remdesivir post hospitalization for COVID-19 infection from the randomized SOLIDARITY Finland trial.

來自芬蘭隨機SOLIDARITY試驗的COVID-19感染住院后remdesivir的效果。

212.Structural insight into Tn3 family transposition mechanism.

對Tn3家族轉(zhuǎn)座機制的結(jié)構(gòu)洞察。

213.A synthetic transcription platform for programmable gene expression in mammalian cells.

用于哺乳動物細胞中可編程基因表達的合成轉(zhuǎn)錄平臺。

214.Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism.

蛋白酶PAPP-A與內(nèi)源性抑制劑stanniocalcin-2的結(jié)構(gòu)揭示了其抑制機制。

215.Genome-wide functional screening of drug-resistance genes in Plasmodium falciparum.

惡性瘧原蟲耐藥基因的全基因組功能篩選。

216.Perception and memory have distinct spatial tuning properties in human visual cortex.

人類視覺皮層中感知和記憶具有不同的空間調(diào)諧特性。

217.Rapid protein assignments and structures from raw NMR spectra with the deep learning technique ARTINA.

利用深度學(xué)習(xí)技術(shù)ARTINA從原始核磁共振光譜中快速分配蛋白質(zhì)和結(jié)構(gòu)。

218.Flexibility of functional neuronal assemblies supports human memory.

功能性神經(jīng)元集合體的靈活性支持人類的記憶。

219.Reprogramming of myeloid cells and their progenitors in patients with non-medullary thyroid carcinoma.

非髓系甲狀腺癌患者骨髓細胞及其祖細胞的重新編程。

220.Actin polymerization promotes invagination of flat clathrin-coated lattices in mammalian cells by pushing at lattice edges.

肌動蛋白聚合通過在晶格邊緣的推動促進哺乳動物細胞中平坦的凝集素涂層晶格的內(nèi)陷。

221.Online single-cell data integration through projecting heterogeneous datasets into a common cell-embedding space.

通過將異質(zhì)數(shù)據(jù)集投射到一個共同的細胞嵌入空間實現(xiàn)在線單細胞數(shù)據(jù)整合。

222.Brain milieu induces early microglial maturation through the BAX-Notch axis.

腦環(huán)境通過BAX-Notch軸誘導(dǎo)早期小膠質(zhì)細胞成熟。

223.Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis.

極化NHE1和SWELL1調(diào)節(jié)遷移方向、效率和轉(zhuǎn)移。

224.HIV-1 CD4-binding site germline antibody–Env structures inform vaccine design.

HIV-1 CD4結(jié)合位點種系抗體-Env結(jié)構(gòu)為疫苗設(shè)計提供參考。

225.Mammalian N1-adenosine PARylation is a reversible DNA modification.

哺乳動物的N1-腺苷PARylation是一種可逆轉(zhuǎn)的DNA修飾。

226.An intrinsic temporal order of c-JUN N-terminal phosphorylation regulates its activity by orchestrating co-factor recruitment.

c-JUN N端磷酸化的內(nèi)在時間順序通過協(xié)調(diào)輔助因子的招募來調(diào)節(jié)其活性。

227.Cryo-EM structures of the translocational binary toxin complex CDTa-bound CDTb-pore from Clostridioides difficile.

艱難梭菌的易位二元毒素復(fù)合物CDTa-結(jié)合CDTb-孔的低溫電鏡結(jié)構(gòu)。

228.The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain.

人類TRPA1內(nèi)在的冷和熱敏感性涉及N-ARD結(jié)構(gòu)域以外的獨立通道結(jié)構(gòu)。

229.Structure of a mitochondrial ribosome with fragmented rRNA in complex with membrane-targeting elements.

帶有片段rRNA的線粒體核糖體與膜靶向元素復(fù)合的結(jié)構(gòu)。

230.Anaerobic oxidation of propane coupled to nitrate reduction by a lineage within the class Symbiobacteriia.

丙烷的厭氧氧化與共生菌類中的一個系的硝酸鹽還原相結(jié)合。

231.SARS-COV-2 antibody responses to AZD1222 vaccination in West Africa.

西非地區(qū)對AZD1222疫苗接種的SARS-COV-2抗體反應(yīng)。

232.Sirtuin5 protects colorectal cancer from DNA damage by keeping nucleotide availability.

Sirtuin5通過保持核苷酸的可用性保護結(jié)直腸癌免受DNA損傷。

233.Vesicular release probability sets the strength of individual Schaffer collateral synapses.

囊泡釋放概率設(shè)定了單個沙弗爾側(cè)枝突觸的強度。

234.ChAd155-RSV vaccine is immunogenic and efficacious against bovine RSV infection-induced disease in young calves.

ChAd155-RSV疫苗對牛RSV感染引起的小牛疾病具有免疫原性和有效性。

235.Comprehensive and clinically accurate head and neck cancer organs-at-risk delineation on a multi-institutional study.

全面的、臨床上準確的頭頸部癌癥風(fēng)險器官劃分對多機構(gòu)研究的影響。

236.A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection.

基于人群的COVID-19疫苗接種和SARS-CoV-2感染后早期妊娠結(jié)果的匹配隊列研究。

237.A scalable platform to discover antimicrobials of ribosomal origin.

發(fā)現(xiàn)核糖體來源的抗菌劑的可擴展平臺。

238.A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma.

局部腫瘤微環(huán)境獲得性超級增強器誘導(dǎo)結(jié)直腸癌的致癌驅(qū)動因素。

239.Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke.

利用人類血漿蛋白組的系統(tǒng)性孟德爾隨機化，發(fā)現(xiàn)潛在的中風(fēng)治療目標。

240.Spatial snapshots of amyloid precursor protein intramembrane processing via early endosome proteomics.

通過早期內(nèi)體蛋白組學(xué)研究淀粉樣前體蛋白膜內(nèi)加工的空間快照。

241.Ex vivo engineered human plasma cells exhibit robust protein secretion and long-term engraftment in vivo.

體外工程人漿細胞表現(xiàn)出強大的蛋白質(zhì)分泌和長期體內(nèi)移植的能力。

242.ATF4-dependent fructolysis fuels growth of glioblastoma multiforme.

ATF4依賴的果實分解助長了多形性膠質(zhì)母細胞瘤的生長。

243.Contrasting life-history responses to climate variability in eastern and western North Pacific sardine populations.

北太平洋東部和西部沙丁魚種群對氣候變異的生活史反應(yīng)截然不同。

244.HSF1 is a driver of leukemia stem cell self-renewal in acute myeloid leukemia.

HSF1是急性骨髓性白血病干細胞自我更新的驅(qū)動因素。

245.In vitro assembly, positioning and contraction of a division ring in minimal cells.

最小細胞中分裂環(huán)的體外組裝、定位和收縮。

246.Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern.

針對SARS-CoV-2變體的多克隆IgG1反應(yīng)中的鑒別交叉反應(yīng)性值得關(guān)注。

247.Maintenance of neurotransmitter identity by Hox proteins through a homeostatic mechanism.

Hox蛋白通過同源機制維持神經(jīng)遞質(zhì)的特性。

248.Structural basis for recognition of antihistamine drug by human histamine receptor.

人類組胺受體識別抗組胺藥物的結(jié)構(gòu)基礎(chǔ)。

249.Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells.

與精神疾病相關(guān)的遺傳變體在淋巴細胞的表觀遺傳活性位點富集。

250.Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airways.

TMPRSS2在SARS-CoV-2感染小鼠氣道中的重要作用。

251.Single-molecule tracking of Nodal and Lefty in live zebrafish embryos supports hindered diffusion model.

活體斑馬魚胚胎中Nodal和Lefty的單分子追蹤支持阻礙性擴散模型。

252.Phase I trial of the TNF-α inhibitor certolizumab plus chemotherapy in stage IV lung adenocarcinomas.

TNF-α抑制劑certolizumab加化療治療IV期肺腺癌的I期試驗。

253.Alignment of single-cell trajectory trees with CAPITAL.

用CAPITAL對準單細胞軌跡樹。

254.Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation.

晝夜節(jié)律蛋白DBP和非典型E2F家族E2F8在抗腫瘤Th9細胞分化中的對立功能。

255.Nanoparticle-based modulation of CD4+ T cell effector and helper functions enhances adoptive immunotherapy.

基于納米顆粒的CD4+T細胞效應(yīng)和輔助功能的調(diào)控增強了采用性免疫療法。

256.Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.

酒精對肝臟芳烴受體的誘導(dǎo)通過PPP2R2D調(diào)控自噬和磷脂代謝。

257.Structure of the core human NADPH oxidase NOX2.

核心人類NADPH氧化酶NOX2的結(jié)構(gòu)。

258.The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement.

IgG的Fab區(qū)在Fc參與后損害了FcRn的內(nèi)化途徑。

259.DNA methylation at birth in monozygotic twins discordant for pediatric acute lymphoblastic leukemia.

小兒急性淋巴細胞白血病單卵雙胞胎出生時的DNA甲基化問題。

260.Solving the MCM paradox by visualizing the scaffold of CMG helicase at active replisomes.

通過可視化活動復(fù)制體上CMG螺旋酶的支架來解決MCM悖論。

261.Genetic map of regional sulcal morphology in the human brain from UK biobank data.

來自英國生物庫數(shù)據(jù)的人腦區(qū)域溝壑形態(tài)的遺傳圖。

262.Ion transfer mechanisms in Mrp-type antiporters from high resolution cryoEM and molecular dynamics simulations.

來自高分辨率低溫電鏡和分子動力學(xué)模擬的Mrp型反輸送器的離子傳輸機制。

263.TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic steatohepatitis.

TLCD1和TLCD2調(diào)節(jié)細胞磷脂酰乙醇胺組成并促進非酒精性脂肪性肝炎的發(fā)展。

264.Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes.

基于免疫肽組學(xué)的針對單核細胞增生李斯特菌的mRNA疫苗配方設(shè)計。

265.Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system.

纖維細胞通過內(nèi)皮素系統(tǒng)促進肺癌龕內(nèi)的腫瘤支持性表型轉(zhuǎn)換。

266.The intestinal clock drives the microbiome to maintain gastrointestinal homeostasis.

腸道時鐘驅(qū)動微生物組以維持胃腸道平衡。

267.Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling.

磷酸酶保護劑α4（α4）通過調(diào)節(jié)胰島素信號參與脂肪細胞維持和線粒體穩(wěn)態(tài)。

268.Hemipiperazines as peptide-derived molecular photoswitches with low-nanomolar cytotoxicity.

Hemipiperazines作為肽衍生的分子光開關(guān)具有低納摩爾的細胞毒性。

269.The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice.

腸道微生物Bacteroides fragilis改善了小鼠的腎臟纖維化狀況。

270.Co-expression of a PD-L1-specific chimeric switch receptor augments the efficacy and persistence of CAR T cells via the CD70-CD27 axis.

PD-L1特異性嵌合開關(guān)受體的共同表達通過CD70-CD27軸增強了CAR T細胞的效力和持久性。

271.The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis.

Hippo途徑將脂肪細胞的可塑性與脂肪組織的纖維化聯(lián)系起來。

272.Chronic intake of high dietary sucrose induces sexually dimorphic metabolic adaptations in mouse liver and adipose tissue.

慢性攝入高膳食蔗糖誘導(dǎo)小鼠肝臟和脂肪組織的性雙態(tài)代謝適應(yīng)。

273.TGF-β-dependent lymphoid tissue residency of stem-like T cells limits response to tumor vaccine.

TGF-β依賴淋巴組織駐留的干性T細胞限制了對腫瘤疫苗的反應(yīng)。

274.Guidance landscapes unveiled by quantitative proteomics to control reinnervation in adult visual system.

定量蛋白質(zhì)組學(xué)揭示了控制成人視覺系統(tǒng)再支配的指導(dǎo)性景觀。

275.Genome-centric analysis of short and long read metagenomes reveals uncharacterized microbiome diversity in Southeast Asians.

以基因組為中心的短讀和長讀元基因組分析揭示了東南亞人未定性的微生物組多樣性。

276.Continuous biomarker monitoring with single molecule resolution by measuring free particle motion.

通過測量自由粒子運動實現(xiàn)單分子分辨率的連續(xù)生物標記物監(jiān)測。