人類 T 淋巴細胞病毒 1 型 HTLV-1 Tax (11-1)，LLFGYPVYV，是一種免疫顯性 HLA-A2 限制性表位。它被 HTLV-1 相關(guān)脊髓病/熱帶痙攣性下肢輕癱 (HAM/TSP) 患者的大量 CD8? 細胞毒性 T 淋巴細胞 (CTL) 識別，這是一種與 HTLV-1 感染相關(guān)的脫髓鞘炎性神經(jīng)系統(tǒng)疾病。因此，LLFGYPVYV 是闡明抗原特異性 CD8? CTL 在 HAM/TSP 中作用的有用工具。

Human T lymphotropic virus type 1 HTLV-1 Tax (11-1), LLFGYPVYV, is an immunodominant HLA-A2-restricted epitope. It is recognized by a high number of CD8? cytotoxic T lymphocytes (CTLs) in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a demyelinating inflammatory neurologic disease associated with HTLV-1 infection. LLFGYPVYV therefore represents a useful tool to elucidate the role of antigen-specific CD8? CTLs in HAM/TSP.

編號: 200168

中文名稱: HTLV-1 Tax (11-19)

CAS號: 141677-18-1

單字母: H2N-LLFGYPVYV-OH

三字母: H2N-Leu-Leu-Phe-Gly-Tyr-Pro-Val-Tyr-Val-COOH

氨基酸個數(shù): 9

分子式: C56H79N9O12

平均分子量: 1070.28

精確分子量: 1069.58

等電點(PI): 10.13

pH=7.0時的凈電荷數(shù): 1.97

平均親水性: -2.2714285714286

疏水性值: 1.67

來源: 人工化學(xué)合成，僅限科學(xué)研究使用，不得用于人體。

儲存條件: 負(fù)80℃至負(fù)20℃

標(biāo)簽: 病毒學(xué)

DOI 名稱

10.1038/nm845 Detection of virus-specific T cells and CD8+ T-cell epitopes by acquisition of peptide-HLA-GFP complexes: analysis of T-cell phenotype and function in chronic viral infections 下載

10.1073/pnas.95.13.7568 Direct visualization of antigen-specific T cells: HTLV-1 Tax11-19- specific CD8(+) T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients 下載

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