聲明：本專欄主要對生命科學領(lǐng)域的一些期刊文章標題進行翻譯，所有內(nèi)容均由本人手工整理翻譯。由于本人專業(yè)為生物分析相關(guān)，其他領(lǐng)域如果出現(xiàn)翻譯錯誤請諒解。

1.Neddylation inhibition induces glutamine uptake and metabolism by targeting CRL3SPOP E3 ligase in cancer cells.

Neddylation抑制通過靶向CRL3SPOP E3連接酶誘導(dǎo)癌細胞對谷氨酰胺的吸收和代謝。

2.STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer.

STING激動劑可重新規(guī)劃腫瘤相關(guān)巨噬細胞，并克服BRCA1缺陷的乳腺癌模型中對PARP抑制的抵抗。

3.The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness.

內(nèi)置 Rbx1 neddylation-Cullin-RING-Ligase 蛋白對于維持調(diào)節(jié)性 T 細胞適應(yīng)性至關(guān)重要。

4.Trophic position of Otodus megalodon and great white sharks through time revealed by zinc isotopes.

鋅同位素揭示了巨齒鯊和大白鯊在時間上的營養(yǎng)地位。

5.Dynamic arrest and aging of biomolecular condensates are modulated by low-complexity domains, RNA and biochemical activity.

生物分子凝聚物的動態(tài)停滯和老化受低復(fù)雜度結(jié)構(gòu)、RNA和生化活動的調(diào)控。

6.Genomic dissection of Klebsiella pneumoniae infections in hospital patients reveals insights into an opportunistic pathogen.

對醫(yī)院患者肺炎克雷伯氏菌感染的基因組剖析揭示了對機會主義病原體的見解。

7.Mapping the cardiac vascular niche in heart failure.

繪制心力衰竭中的心臟血管龕。

8.Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.

人A2ML1的低溫電鏡結(jié)構(gòu)闡明了A2M家族的蛋白酶抑制機制。

9.Structural variant-based pangenome construction has low sensitivity to variability of haplotype-resolved bovine assemblies.

基于結(jié)構(gòu)變異的pangenome構(gòu)建對解決了單倍型的牛集合體的變異性具有低敏感性。

10.P-selectin mobility undergoes a sol-gel transition as it diffuses from exocytosis sites into the cell membrane.

P-選擇素的流動性經(jīng)歷了溶膠-凝膠的轉(zhuǎn)變，因為它從細胞外分泌部位擴散到細胞膜。

11.Dosage-sensitive miRNAs trigger modulation of gene expression during genomic imbalance in maize.

劑量敏感的miRNA在玉米基因組失衡期間引發(fā)基因表達的調(diào)控。

12.A framework for reconstructing SARS-CoV-2 transmission dynamics using excess mortality data.

利用超額死亡數(shù)據(jù)重建SARS-CoV-2傳播動態(tài)的框架。

13.BRD4 promotes resection and homology-directed repair of DNA double-strand breaks.

BRD4促進DNA雙鏈斷裂的切除和同源定向修復(fù)。

14.Modular (de)construction of complex bacterial phenotypes by CRISPR/nCas9-assisted, multiplex cytidine base-editing.

通過CRISPR/nCas9輔助的多重胞苷堿基編輯，對復(fù)雜細菌表型進行模塊化（去）構(gòu)建。

15.Computationally designed hyperactive Cas9 enzymes.

計算設(shè)計的超活性Cas9酶。

16.Multicenter phase II trial of Camrelizumab combined with Apatinib and Eribulin in heavily pretreated patients with advanced triple-negative breast cancer.

Camrelizumab聯(lián)合Apatinib和Eribulin在重度預(yù)處理的晚期三陰性乳腺癌患者中的多中心II期試驗。

17.Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure.

用VHH體內(nèi)抗體阻斷phospholamban可增強心力衰竭的收縮性和放松性。

18.Omega-3 fatty acid epoxides produced by PAF-AH2 in mast cells regulate pulmonary vascular remodeling.

肥大細胞中PAF-AH2產(chǎn)生的Omega-3脂肪酸環(huán)氧化物調(diào)節(jié)肺血管重塑。

19.Open-source personal pipetting robots with live-cell incubation and microscopy compatibility.

具有活細胞孵化和顯微鏡兼容性的開源個人移液機器人。

20.A cancer-associated RNA polymerase III identity drives robust transcription and expression of snaR-A noncoding RNA.

一個與癌癥相關(guān)的RNA聚合酶III身份驅(qū)動snaR-A非編碼RNA的強健轉(zhuǎn)錄和表達。

21.Identification of positive and negative regulators of antiviral RNA interference in Arabidopsis thaliana.

鑒定擬南芥中抗病毒RNA干擾的正負調(diào)節(jié)器。

22.Switches, stability and reversals in the evolutionary history of sexual systems in fish.

魚類性系統(tǒng)進化史中的切換、穩(wěn)定和逆轉(zhuǎn)。

23.Myriapod genomes reveal ancestral horizontal gene transfer and hormonal gene loss in millipedes.

Myriapod genomes揭示了千足蟲的祖先水平基因轉(zhuǎn)移和荷爾蒙基因損失。

24.Cellular and genetic drivers of RNA editing variation in the human brain.

人腦中RNA編輯變異的細胞和遺傳驅(qū)動因素。

25.CRISPR/Cas9 gRNA activity depends on free energy changes and on the target PAM context.

CRISPR/Cas9 gRNA的活性取決于自由能變化和目標PAM背景。

26.Long-term hepatitis B virus infection of rhesus macaques requires suppression of host immunity.

恒河猴的長期乙肝病毒感染需要抑制宿主免疫力。

27.Stochastic expression of invasion genes in Plasmodium falciparum schizonts.

惡性瘧原蟲裂殖體中侵襲基因的隨機表達.

28.A lncRNA signature associated with tumor immune heterogeneity predicts distant metastasis in locoregionally advanced nasopharyngeal carcinoma.

與腫瘤免疫異質(zhì)性相關(guān)的lncRNA簽名可預(yù)測局部區(qū)域晚期鼻咽癌的遠處轉(zhuǎn)移。

29.Transmission of SARS-CoV-2 from humans to animals and potential host adaptation.

SARS-CoV-2從人到動物的傳播及潛在的宿主適應(yīng)性。

30.Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C.

針對SARS-CoV-2 Omicron變體的交叉反應(yīng)性免疫在曾患COVID-19或MIS-C的小兒患者中很低。

31.Improving recombinant protein production by yeast through genome-scale modeling using proteome constraints.

利用蛋白質(zhì)組的約束條件，通過基因組規(guī)模的建模來改進酵母的重組蛋白生產(chǎn)。

32.Molecular encoding and synaptic decoding of context during salt chemotaxis in C. elegans.

秀麗亞馬遜的鹽類趨化過程中上下文的分子編碼和突觸解碼。

33.Activation of Nkx2.5 transcriptional program is required for adult myocardial repair.

激活Nkx2.5轉(zhuǎn)錄程序是成人心肌修復(fù)的需要。

34.Structural basis for broad anti-phage immunity by DISARM.

DISARM的廣泛抗噬菌體免疫的結(jié)構(gòu)基礎(chǔ)。

35.Histone functions as a cell-surface receptor for AGEs.

組蛋白作為AGEs的細胞表面受體的功能。

36.PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling.

PI(18:1/18:1)是一種SCD1衍生的脂質(zhì)因子，可限制壓力信號的傳遞。

37.SpotClean adjusts for spot swapping in spatial transcriptomics data.

SpotClean調(diào)整了空間轉(zhuǎn)錄組學數(shù)據(jù)中的斑點互換。

38.Fluent molecular mixing of Tau isoforms in Alzheimer’s disease neurofibrillary tangles.

阿爾茨海默病神經(jīng)纖維纏結(jié)中Tau異構(gòu)體的流暢分子混合。

39.Gene-specific nonsense-mediated mRNA decay targeting for cystic fibrosis therapy.

用于囊性纖維化治療的基因特異性無義介導(dǎo)的mRNA衰變靶點。

40.Nitrogen represses haustoria formation through abscisic acid in the parasitic plant Phtheirospermum japonicum.

氮氣通過赤霉酸抑制寄生植物Phtheirospermum japonicum的毛細管形成。

41.Automated vitrification of cryo-EM samples with controllable sample thickness using suction and real-time optical inspection.

利用吸力和實時光學檢查，對冷凍電子顯微鏡樣品進行自動玻璃化，樣品厚度可控。

42.Rewritable two-dimensional DNA-based data storage with machine learning reconstruction.

可重寫的基于DNA的二維數(shù)據(jù)存儲與機器學習重建。

43.Prosocial correlates of transformative experiences at secular multi-day mass gatherings.

在世俗的多日群眾集會中，變革性經(jīng)歷的親社會相關(guān)因素。

44.Complexity of biological scaling suggests an absence of systematic trade-offs between sensory modalities in Drosophila.

生物縮放的復(fù)雜性表明果蠅的感覺模式之間缺乏系統(tǒng)的權(quán)衡。

45.RNase H2, mutated in Aicardi‐Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation.

在Aicardi-Goutières綜合征中發(fā)生突變的RNase H2解決了共同轉(zhuǎn)錄的R環(huán)以防止DNA斷裂和炎癥。

46.Insights into methionine S-methylation in diverse organisms.

對不同生物體中蛋氨酸S-甲基化的深入了解。

47.An integral genomic signature approach for tailored cancer therapy using genome-wide sequencing data.

利用全基因組測序數(shù)據(jù)進行定制化癌癥治療的整體基因組特征方法。

48.Single-cell chromatin profiling of the primitive gut tube reveals regulatory dynamics underlying lineage fate decisions.

原始腸管的單細胞染色質(zhì)剖析揭示了線型命運決定的調(diào)控動態(tài)。

49.Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2.

Omicron BA.1對BA.2和BA.3 SARS-CoV-2的交叉中立化。

50.Multiomics reveals persistence of obesity-associated immune cell phenotypes in adipose tissue during weight loss and weight regain in mice.

多組學揭示了小鼠減肥和體重恢復(fù)期間脂肪組織中肥胖相關(guān)的免疫細胞表型的持久性。

51.The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase.

長非編碼RNA ADIPINT通過丙酮酸羧化酶調(diào)控人類脂肪細胞的代謝。

52.Transgenic Anopheles mosquitoes expressing human PAI-1 impair malaria transmission.

表達人PAI-1的轉(zhuǎn)基因按蚊損害了瘧疾傳播。

53.Genomic analyses of 10,376 individuals in the Westlake BioBank for Chinese (WBBC) pilot project.

西湖區(qū)中國人生物庫（WBBC）試點項目中10376人的基因組分析。

54.A topological refactoring design strategy yields highly stable granulopoietic proteins.

一種拓撲重構(gòu)設(shè)計策略產(chǎn)生了高度穩(wěn)定的粒細胞蛋白。

55.Locomotion-induced ocular motor behavior in larval Xenopus is developmentally tuned by visuo-vestibular reflexes.

幼年Xenopus的運動誘導(dǎo)的眼球運動行為在發(fā)育過程中受到視覺-前庭反射的調(diào)整。

56.SARS-CoV-2 ORF7a potently inhibits the antiviral effect of the host factor SERINC5.

SARS-CoV-2 ORF7a有力地抑制了宿主因子SERINC5的抗病毒作用。

57.SARS-CoV-2 accessory proteins reveal distinct serological signatures in children.

SARS-CoV-2的附屬蛋白顯示了兒童中不同的血清學特征。

58.Depletion of skeletal muscle satellite cells attenuates pathology in muscular dystrophy.

骨骼肌衛(wèi)星細胞的耗竭減輕了肌肉萎縮癥的病理變化。

59.Homophilic ATP1A1 binding induces activin A secretion to promote EMT of tumor cells and myofibroblast activation.

同源ATP1A1結(jié)合誘導(dǎo)激活素A的分泌，促進腫瘤細胞的EMT和肌成纖維細胞的激活。

60.Combining rapid antigen testing and syndromic surveillance improves community-based COVID-19 detection in a low-income country.

結(jié)合快速抗原檢測和綜合癥監(jiān)測，改善低收入國家的社區(qū)COVID-19檢測。

61.The case for increasing diversity in tissue-based functional genomics datasets to understand human disease susceptibility.

增加基于組織的功能基因組學數(shù)據(jù)集的多樣性以了解人類疾病易感性的案例。

62.Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer.

用高選擇性的抑制劑針對雙特異性的酪氨酸磷酸化調(diào)節(jié)激酶2來治療前列腺癌。

63.The potential of polygenic scores to improve cost and efficiency of clinical trials.

多基因評分在提高臨床試驗的成本和效率方面的潛力。

64.Mutational signatures are markers of drug sensitivity of cancer cells.

突變特征是癌細胞藥物敏感性的標志。

65.Peptide nano-blanket impedes fibroblasts activation and subsequent formation of pre-metastatic niche.

肽納米毯阻礙了成纖維細胞的激活和隨后轉(zhuǎn)移前龕的形成。

66.O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine.

O-GlcNAc修飾的leucyl-tRNA合成酶1整合了亮氨酸和葡萄糖的可用性以調(diào)節(jié)mTORC1和亮氨酸的代謝命運。

67.Serotonin limits generation of chromaffin cells during adrenal organ development.

羥色胺限制了腎上腺器官發(fā)育過程中絨毛細胞的生成。

68.Biogenesis of a bacterial metabolosome for propanediol utilization.

利用丙二醇的細菌代謝體的生物生成。

69.Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity.

嗅覺神經(jīng)元對GPCR特性和活性的轉(zhuǎn)錄適應(yīng)。

70.Molecular mechanism of the wake-promoting agent TAK-925.

促醒劑TAK-925的分子機制。

71.Functional and multiscale 3D structural investigation of brain tissue through correlative in vivo physiology, synchrotron microtomography and volume electron microscopy.

通過相關(guān)的體內(nèi)生理學、同步輻射顯微鏡和體積電子顯微鏡對腦組織進行功能和多尺度三維結(jié)構(gòu)調(diào)查。

72.Cell type-specific biotin labeling in vivo resolves regional neuronal and astrocyte proteomic differences in mouse brain.

細胞類型特異性生物素標記在體內(nèi)解決了小鼠大腦中區(qū)域神經(jīng)元和星形細胞蛋白質(zhì)組的差異。

73.A high-throughput multiparameter screen for accelerated development and optimization of soluble genetically encoded fluorescent biosensors.

用于加速開發(fā)和優(yōu)化可溶性基因編碼熒光生物傳感器的高通量多參數(shù)篩選。

74.Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes.

人類冠狀病毒OC43尖峰的抗原結(jié)構(gòu)揭示了暴露和閉塞的中和表位。

75.Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via TLR4 in rodent models of spinal cord injury.

硫酸軟骨素蛋白聚糖通過TLR4在脊髓損傷的嚙齒動物模型中防止免疫細胞表型轉(zhuǎn)換和炎癥解決。

76.Dynamic stiffening of the flagellar hook.

鞭毛鉤的動態(tài)變硬。

77.The 3′ Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies’ association with histone locus bodies.

復(fù)制依賴性組蛋白基因的3′Pol II停頓是由Mediator通過Cajal體與組蛋白基因座體的關(guān)聯(lián)來調(diào)節(jié)的。

78.The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer.

Cdc7-Dbf4激酶對MCM2-7雙六聚體的定向和磷酸化的結(jié)構(gòu)基礎(chǔ)。

79.Seeking patterns of antibiotic resistance in ATLAS, an open, raw MIC database with patient metadata.

在ATLAS中尋找抗生素耐藥性模式，這是一個開放的、帶有病人元數(shù)據(jù)的原始MIC數(shù)據(jù)庫。

80.Exact simulation of pigment-protein complexes unveils vibronic renormalization of electronic parameters in ultrafast spectroscopy.

顏料-蛋白質(zhì)復(fù)合物的精確模擬揭示了超快光譜學中電子參數(shù)的振子重正化。

81.Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration.

非酒精性脂肪性肝炎和減肥手術(shù)對肝臟和脂肪組織線粒體生物生成和呼吸的影響。

82.Predicting cancer prognosis and drug response from the tumor microbiome.

從腫瘤微生物組預(yù)測癌癥的預(yù)后和藥物反應(yīng)。

83.Competent immune responses to SARS-CoV-2 variants in older adults following two doses of mRNA vaccination.

兩劑mRNA疫苗接種后老年人對SARS-CoV-2變體的合格免疫反應(yīng).

84.Robust temporal map of human in vitro myelopoiesis using single-cell genomics.

利用單細胞基因組學繪制人類體外骨髓造血的穩(wěn)健時間圖。

85.Mothers with higher twinning propensity had lower fertility in pre-industrial Europe.

在工業(yè)化前的歐洲，具有較高雙胞胎傾向的母親的生育率較低。

86.A framework to efficiently describe and share reproducible DNA materials and construction protocols.

一個有效描述和分享可重復(fù)的DNA材料和構(gòu)建協(xié)議的框架。

87.The RNA-bound proteome of MRSA reveals post-transcriptional roles for helix-turn-helix DNA-binding and Rossmann-fold proteins.

MRSA的RNA結(jié)合蛋白組揭示了螺旋轉(zhuǎn)螺旋DNA結(jié)合和羅斯曼折疊蛋白的轉(zhuǎn)錄后作用。

88.Anoctamin 1 controls bone resorption by coupling Cl? channel activation with RANKL-RANK signaling transduction.

Anoctamin 1通過耦合Cl-通道激活和RANKL-RANK信號轉(zhuǎn)導(dǎo)來控制骨吸收。

89.An in vivo gene amplification system for high level expression in Saccharomyces cerevisiae.

酵母菌高水平表達的體內(nèi)基因擴增系統(tǒng)。

90.Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.

來自低溫電鏡集合分析的Vanilloid依賴的TRPV1開放軌跡。

91.Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1.

譯碼器合成聚合酶Rev1的核苷酸識別機制。

92.Exceptional parallelisms characterize the evolutionary transition to live birth in phrynosomatid lizards.

異常的平行性是phrynosomatid蜥蜴向活產(chǎn)的進化過渡的特征。

93.Functional expression of opioid receptors and other human GPCRs in yeast engineered to produce human sterols.

阿片類受體和其他人類GPCRs在工程化生產(chǎn)人類甾醇的酵母中的功能表達。

94.Auditory processing remains sensitive to environmental experience during adolescence in a rodent model.

在嚙齒動物模型中，聽覺處理對青少年時期的環(huán)境經(jīng)驗仍然敏感。

95.Off-season RSV epidemics in Australia after easing of COVID-19 restrictions.

放寬COVID-19限制后澳大利亞的RSV淡季流行。

96.Addressing the socioeconomic divide in computational modeling for infectious diseases.

應(yīng)對傳染病計算模型中的社會經(jīng)濟鴻溝。

97.Metabolic regulation by the intestinal metformin-AMPK axis.

腸道二甲雙胍-AMPK軸的代謝調(diào)節(jié)。

98.Comments on identifying causal relationships in nonlinear dynamical systems via empirical mode decomposition.

關(guān)于通過經(jīng)驗?zāi)Ｊ椒纸庾R別非線性動態(tài)系統(tǒng)中的因果關(guān)系的評論.

99.Reply To: Comments on identifying causal relationships in nonlinear dynamical systems via empirical mode decomposition.

Reply To： 關(guān)于通過經(jīng)驗?zāi)Ｊ椒纸庾R別非線性動力系統(tǒng)中的因果關(guān)系的評論。

100.Signal requirement for cortical potential of transplantable human neuroepithelial stem cells.

移植的人類神經(jīng)上皮干細胞的皮質(zhì)潛力的信號要求。

101.p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis.

表達胎兒基因特征的p53野生型結(jié)直腸癌細胞與轉(zhuǎn)移和預(yù)后不良有關(guān)。

102.Cell cycle gene regulation dynamics revealed by RNA velocity and deep-learning.

通過RNA速度和深度學習揭示細胞周期基因調(diào)控動態(tài)。

103.The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands.

不同配體對毒蕈堿受體M4R的非常規(guī)激活.

104.Multisensory task demands temporally extend the causal requirement for visual cortex in perception.

多感官任務(wù)需求在時間上擴展了視覺皮層在感知方面的因果要求。

105.Extracellular vimentin mimics VEGF and is a target for anti-angiogenic immunotherapy.

細胞外波形蛋白模擬VEGF，是抗血管生成免疫療法的目標。

106.Structural insights into the mechanism of archaellar rotational switching.

對弓形體旋轉(zhuǎn)切換機制的結(jié)構(gòu)性見解。

107.Synthetic lethality between TP53 and ENDOD1.

TP53和ENDOD1之間的合成致死性。

108.Origins of direction selectivity in the primate retina.

靈長類動物視網(wǎng)膜中方向選擇性的起源。

109.ADAMTS4-specific MR probe to assess aortic aneurysms in vivo using synthetic peptide libraries.

利用合成肽庫評估體內(nèi)主動脈瘤的ADAMTS4特異性MR探針。

110.A genetic engineering strategy for editing near-infrared-II fluorophores.

編輯近紅外-II型熒光團的基因工程策略。

111.Complex dynamics in a synchronized cell-free genetic clock.

同步的無細胞遺傳鐘中的復(fù)雜動態(tài)。

112.Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations.

心臟yanodine受體門控的分子基礎(chǔ)解釋了功能獲得和喪失的突變機制。

113.Limiting motorboat noise on coral reefs boosts fish reproductive success.

限制珊瑚礁上的摩托艇噪音可提高魚類的繁殖成功率。

114.Insights into the client protein release mechanism of the ATP-independent chaperone Spy.

對ATP非依賴性伴侶蛋白Spy的客戶蛋白釋放機制的見解。

115.Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells.

抑制CDK2和Cyclin A復(fù)合物導(dǎo)致癌細胞中CDK2的自噬性降解。

116.Automated next-generation profiling of genomic alterations in human cancers.

人類癌癥中基因組改變的自動化下一代分析。

117.Proteome allocations change linearly with the specific growth rate of Saccharomyces cerevisiae under glucose limitation.

蛋白質(zhì)組分配與葡萄糖限制下的釀酒酵母的特定生長速度呈線性變化。

118.Metabolic control of progenitor cell propagation during Drosophila tracheal remodeling.

果蠅氣管重塑過程中對祖細胞繁殖的代謝控制。

119.A 3D gene expression atlas of the floral meristem based on spatial reconstruction of single nucleus RNA sequencing data.

基于單核RNA測序數(shù)據(jù)空間重建的花分生組織三維基因表達圖譜。

120.Codon-specific Ramachandran plots show amino acid backbone conformation depends on identity of the translated codon.

特定密碼子的拉馬錢德蘭圖顯示氨基酸骨架的構(gòu)象取決于翻譯密碼子的身份。

121.Reply to “Marine abundance and its prehistoric past in the Baltic”.

對 "波羅的海的海洋豐度及其史前歷史 "的答復(fù)。

122.Dynamic character displacement among a pair of bacterial phyllosphere commensals in situ.

一對細菌植物圈共生體在原地的動態(tài)特征位移。

123.Engineered Cas12i2 is a versatile high-efficiency platform for therapeutic genome editing.

工程化的Cas12i2是治療性基因組編輯的多功能高效平臺。

124.Structural rearrangements allow nucleic acid discrimination by type I-D Cascade.

結(jié)構(gòu)重排允許I-D型級聯(lián)的核酸辨別。

125.Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis.

納米粒子增強放療與PD-L1阻斷協(xié)同作用，限制手術(shù)后癌癥復(fù)發(fā)和轉(zhuǎn)移。

126.Inhibition mechanism of the chloride channel TMEM16A by the pore blocker 1PBC.

孔隙阻斷劑1PBC對氯通道TMEM16A的抑制機制。

127.RNA supply drives physiological granule assembly in neurons.

RNA供應(yīng)驅(qū)動神經(jīng)元中的生理性顆粒組裝。

128.Topography-induced large-scale antiparallel collective migration in vascular endothelium.

拓撲結(jié)構(gòu)誘導(dǎo)的血管內(nèi)皮細胞大規(guī)模反平行集體遷移。

129.Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment.

線粒體鈣離子單體穩(wěn)定化在復(fù)合體I損傷期間保持能量平衡。

130.Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.

通過低溫電鏡揭示C9ORF72-ALS/FTD相關(guān)的聚PR和聚GR蛋白對核糖體的抑制。

131.Frequency modulation of a bacterial quorum sensing response.

細菌法定人數(shù)感應(yīng)反應(yīng)的頻率調(diào)節(jié)。

132.The ubiquitin ligase Cul5 regulates CD4+ T cell fate choice and allergic inflammation.

泛素連接酶Cul5調(diào)控CD4+T細胞命運選擇和過敏性炎癥。

133.The phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cells.

磷酸酶PTEN將血小板與小鼠T濾泡輔助細胞的免疫調(diào)節(jié)功能聯(lián)系起來。

134.A truncated anti-CRISPR protein prevents spacer acquisition but not interference.

一種截短的抗CRISPR蛋白能阻止間隔物的獲得，但不能阻止干擾。

135.Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitro.

廣譜CRISPR介導(dǎo)的體外SARS-CoV-2變體和地方性冠狀病毒的抑制。

136.BMP4 drives primed to na?ve transition through PGC-like state.

BMP4通過PGC樣態(tài)驅(qū)動初生到幼稚的轉(zhuǎn)變。

137.C. elegans enteric motor neurons fire synchronized action potentials underlying the defecation motor program.

秀麗隱士的腸道運動神經(jīng)元發(fā)射同步的動作電位，這是排便運動程序的基礎(chǔ)。

138.RNP components condense into repressive RNP granules in the aging brain.

衰老的大腦中RNP成分凝聚成壓抑性RNP顆粒。

139.Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia.

抑制線粒體復(fù)合體I可逆轉(zhuǎn)NOTCH1驅(qū)動的T細胞急性淋巴細胞白血病的代謝重編程。

140.Multiplex base- and prime-editing with drive-and-process CRISPR arrays.

用驅(qū)動和處理CRISPR陣列進行多重堿基和引物編輯。

141.Optogenetic manipulation and photoacoustic imaging using a near-infrared transgenic mouse model.

利用近紅外轉(zhuǎn)基因小鼠模型進行光遺傳學操作和光聲成像。

142.SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity.

SARS-CoV-2感染導(dǎo)致呼吸道和外周血的免疫反應(yīng)，提示疾病的嚴重性機制。

143.RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer.

RNA剪接是腫瘤細胞可塑性的關(guān)鍵媒介，也是結(jié)直腸癌的治療弱點。

144.Structural insights into the mechanism of pancreatic KATP channel regulation by nucleotides.

胰腺KATP通道受核苷酸調(diào)控機制的結(jié)構(gòu)見解。

145.Neuronal hyperexcitability drives central and peripheral nervous system tumor progression in models of neurofibromatosis-1.

神經(jīng)元過度興奮促使神經(jīng)纖維瘤病-1模型中的中樞和外周神經(jīng)系統(tǒng)腫瘤的發(fā)展。

146.Plant beta-diversity across biomes captured by imaging spectroscopy.

成像光譜學捕獲的跨生物群落的植物β多樣性。

147.Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine.

麻醉劑dyclonine抑制TRPV3通道的結(jié)構(gòu)機制。

148.Templated folding of the RTX domain of the bacterial toxin adenylate cyclase revealed by single molecule force spectroscopy.

單分子力譜學揭示細菌毒素腺苷酸環(huán)化酶RTX結(jié)構(gòu)域的模板化折疊。

149.A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway.

一種通過調(diào)控NRF2信號通路防止視網(wǎng)膜瘢痕的生物功能聚合物。

150.Modulation of biological motion perception in humans by gravity.

重力對人類生物運動感知的調(diào)控。

151.Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients.

不同的熱點p53突變體發(fā)揮著不同的表型，并預(yù)測結(jié)直腸癌患者的結(jié)局。

152.PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression.

PRRX1是基質(zhì)成纖維細胞的主轉(zhuǎn)錄因子，用于肌成纖維細胞系的進展。

153.TUBB4A interacts with MYH9 to protect the nucleus during cell migration and promotes prostate cancer via GSK3β/β-catenin signalling.

TUBB4A與MYH9相互作用，在細胞遷移過程中保護細胞核，并通過GSK3β/β-catenin信號傳導(dǎo)促進前列腺癌。

154.Shielding of actin by the endoplasmic reticulum impacts nuclear positioning.

內(nèi)質(zhì)網(wǎng)對肌動蛋白的屏蔽影響核定位。

155.Elimination of human rabies in Goa, India through an integrated One Health approach.

印度果阿通過 "一個健康 "的綜合方法消除了人類狂犬病。

156.Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy.

Cryo-EM結(jié)構(gòu)確定了泛醌-10與線粒體復(fù)合體I的結(jié)合以及伴隨Q位點占用的構(gòu)象轉(zhuǎn)換。

157.Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts.

通過調(diào)節(jié)癌癥相關(guān)的成纖維細胞逆轉(zhuǎn)光熱療法誘發(fā)的腫瘤復(fù)發(fā)和轉(zhuǎn)移的不足。

158.Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD.

腦脊液中的聚（GR）和聚（GA）作為C9ORF72-ALS/FTD的潛在生物標志物。

159.SARS-CoV-2 transmission and impacts of unvaccinated-only screening in populations of mixed vaccination status.

SARS-CoV-2的傳播以及在混合疫苗接種狀態(tài)的人群中只進行未接種疫苗篩查的影響。

160.Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells.

目標受體的識別和隨后用封裝和工程異體干細胞治療切除的腦腫瘤。

161.A deep learning model and human-machine fusion for prediction of EBV-associated gastric cancer from histopathology.

深度學習模型和人機融合，從組織病理學上預(yù)測EB病毒相關(guān)的胃癌。

162.The use of single-cell multi-omics in immuno-oncology.

單細胞多組學在免疫腫瘤學中的應(yīng)用。

163.Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation.

鏈球菌Siglec樣粘附物中糖類選擇性的起源表明受體適應(yīng)機制。

164.Novel role of the synaptic scaffold protein Dlgap4 in ventricular surface integrity and neuronal migration during cortical development.

突觸支架蛋白Dlgap4在大腦皮層發(fā)育過程中腦室表面完整性和神經(jīng)元遷移中的新作用。

165.Large-scale GWAS of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits.

食物喜好的大規(guī)模GWAS揭示了遺傳決定因素和與不同神經(jīng)生理特征的遺傳相關(guān)性。

166.Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates.

去泛素化酶和蛋白酶體調(diào)節(jié)泛素底物的優(yōu)選集。

167.Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide.

利尿藥布美他尼抑制陽離子-氯化物共轉(zhuǎn)運體NKCC1的結(jié)構(gòu)基礎(chǔ)。

168.Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas.

相變和重塑復(fù)合物的組裝對滑膜肉瘤的SS18-SSX致癌活性很重要。

169.HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.

HDLBP通過多價相互作用結(jié)合ER靶向的mRNA，促進跨膜和分泌蛋白的蛋白質(zhì)合成。

170.Autophagy regulation by RNA alternative splicing and implications in human diseases.

RNA替代剪接對自噬的調(diào)控及對人類疾病的影響。

171.The planarian wound epidermis gene equinox is required for blastema formation in regeneration.

胎生動物的傷口表皮基因equinox在再生過程中需要形成囊膜。

172.Tempo and drivers of plant diversification in the European mountain system.

歐洲山地系統(tǒng)中植物多樣化的速度和驅(qū)動因素。

173.Visual barcodes for clonal-multiplexing of live microscopy-based assays.

基于活體顯微鏡檢測的克隆復(fù)用的視覺條碼。

174.Extended intergenic DNA contributes to neuron-specific expression of neighboring genes in the mammalian nervous system.

延伸的基因間DNA有助于哺乳動物神經(jīng)系統(tǒng)中鄰近基因的神經(jīng)元特異性表達。

175.Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers.

兒科和年輕成人癌癥的全基因組和轉(zhuǎn)錄組分析的可行性。

176.Global diversity dynamics in the fossil record are regionally heterogeneous.

化石記錄中的全球多樣性動態(tài)是區(qū)域性的異質(zhì)性的。

177.Extensible and self-recoverable proteinaceous materials derived from scallop byssal thread.

源自扇貝貝殼線的可擴展和可自我恢復(fù)的蛋白材料。

178.IL-1R-IRAKM-Slc25a1 signaling axis reprograms lipogenesis in adipocytes to promote diet-induced obesity in mice.

IL-1R-IRAKM-Slc25a1信號軸重新規(guī)劃脂肪細胞的脂肪生成以促進飲食誘導(dǎo)的小鼠肥胖。

179.Co-infection with SARS-CoV-2 Omicron and Delta variants revealed by genomic surveillance.

基因組監(jiān)測揭示SARS-CoV-2 Omicron和Delta變種的共同感染。

180.Mutational landscape of normal epithelial cells in Lynch Syndrome patients.

林奇綜合征患者正常上皮細胞的突變景觀。

181.A Middle Pleistocene Denisovan molar from the Annamite Chain of northern Laos.

老撾北部Annamite鏈的中更新世丹尼索瓦人臼齒。

182.Differential regulation of alternative promoters emerges from unified kinetics of enhancer-promoter interaction.

從增強子-促進子相互作用的統(tǒng)一動力學中出現(xiàn)的替代性啟動子的不同調(diào)節(jié)。

183.N-type fast inactivation of a eukaryotic voltage-gated sodium channel.

真核細胞電壓門控鈉通道的N型快速失活。

184.Cortical Cyclin A controls spindle orientation during asymmetric cell divisions in Drosophila.

果蠅不對稱細胞分裂過程中皮質(zhì)環(huán)蛋白A控制紡錘體方向。

185.Intelligent wireless theranostic contact lens for electrical sensing and regulation of intraocular pressure.

智能無線治療儀接觸鏡對眼內(nèi)壓的電感應(yīng)和調(diào)節(jié)。

186.Nucleotide-amino acid π-stacking interactions initiate photo cross-linking in RNA-protein complexes.

核苷酸-氨基酸π型堆積相互作用啟動了RNA-蛋白質(zhì)復(fù)合物中的光交聯(lián)。

187.Deep learning modeling m6A deposition reveals the importance of downstream cis-element sequences.

深度學習建模的m6A沉積揭示了下游順式元素序列的重要性。

188.Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms.

增強劑調(diào)節(jié)3′端加工活性以控制替代3′UTR異構(gòu)體的表達。

189.Mineralogical control on methylotrophic methanogenesis and implications for cryptic methane cycling in marine surface sediment.

礦物學對甲基化甲烷生成的控制以及對海洋表層沉積物中隱性甲烷循環(huán)的影響。

190.Targeted detection of cancer at the cellular level during biopsy by near-infrared confocal laser endomicroscopy.

近紅外共聚焦激光內(nèi)窺鏡在活檢過程中在細胞水平上對癌癥的定向檢測。

191.Human-ignited fires result in more extreme fire behavior and ecosystem impacts.

人類引發(fā)的火災(zāi)導(dǎo)致更極端的火災(zāi)行為和生態(tài)系統(tǒng)的影響。

192.Ranking threats to biodiversity and why it doesn’t matter.

對生物多樣性的威脅進行排序，以及為什么它并不重要。

193.Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists.

蛋白激酶C C1結(jié)構(gòu)域與二酰甘油和其他激動劑相互作用的結(jié)構(gòu)解剖。

194.A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs.

一個保守的YAP/Notch/REST網(wǎng)絡(luò)控制著肺部的神經(jīng)內(nèi)分泌細胞命運。

195.Ca2+-mediated higher-order assembly of heterodimers in amino acid transport system b0,+ biogenesis and cystinuria.

氨基酸運輸系統(tǒng)b0,+生物生成和胱氨酸尿癥中Ca2+介導(dǎo)的異質(zhì)體高階組裝。

196.Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses.

過度磷酸化的tau自組裝成無定形聚合體，引起TLR4依賴性反應(yīng)。

197.Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis.

線粒體保持自律性單碳循環(huán)以賦予生長無關(guān)的癌細胞遷移和轉(zhuǎn)移。

198.Identification of a modulator of the actin cytoskeleton, mitochondria, nutrient metabolism and lifespan in yeast.

鑒定酵母中肌動蛋白細胞骨架、線粒體、營養(yǎng)代謝和壽命的調(diào)節(jié)劑。

199.PlasmidMaker is a versatile, automated, and high throughput end-to-end platform for plasmid construction.

PlasmidMaker是一個多功能、自動化、高通量的端到端質(zhì)粒構(gòu)建平臺。

200.Cooperative regulation of PBI1 and MAPKs controls WRKY45 transcription factor in rice immunity.

PBI1和MAPKs的合作調(diào)控控制水稻免疫中的WRKY45轉(zhuǎn)錄因子。

201.Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells.

老年造血干細胞染色質(zhì)可及性中的表觀遺傳特征。

202.POD1-SUN-CRT3 chaperone complex guards the ER sorting of LRR receptor kinases in Arabidopsis.

POD1-SUN-CRT3伴侶復(fù)合物守護著擬南芥中LRR受體激酶的ER排序。

203.A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases.

控制核糖核酸還原酶NrdR依賴性轉(zhuǎn)錄的核糖核酸感應(yīng)寡聚機制。

204.Polymer-coated carbon nanotube hybrids with functional peptides for gene delivery into plant mitochondria.

聚合物包覆的碳納米管與功能肽的混合體用于基因傳遞到植物線粒體。

205.Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway.

嘌呤核苷酸的耗竭通過刺激絲氨酸合成途徑促使細胞遷移。

206.A mathematical perspective on edge-centric brain functional connectivity.

以邊緣為中心的大腦功能連接的數(shù)學視角。

207.Multifunctional metal-organic framework-based nanoreactor for starvation/oxidation improved indoleamine 2,3-dioxygenase-blockade tumor immunotherapy.

基于金屬有機框架的多功能納米反應(yīng)器用于饑餓/氧化改善吲哚胺2,3-二氧酶阻斷的腫瘤免疫治療。

208.An Artificial Intelligence-guided signature reveals the shared host immune response in MIS-C and Kawasaki disease.

人工智能指導(dǎo)下的簽名揭示了MIS-C和川崎病的共同宿主免疫反應(yīng)。

209.Learnings from Thailand in building strong surveillance for malaria elimination.

從泰國吸取經(jīng)驗教訓，為消除瘧疾建立強有力的監(jiān)控。

210.Tackling malaria transmission at a single cell level in an endemic setting in sub-Saharan Africa.

在撒哈拉以南非洲的流行環(huán)境中，在單細胞水平上解決瘧疾傳播問題。

211.Malaria in 2022: Increasing challenges, cautious optimism.

2022年的瘧疾：越來越多的挑戰(zhàn)，謹慎的樂觀。

212.A broader perspective on the economics of malaria prevention and the potential impact of SARS-CoV-2.

從更廣泛的角度來看瘧疾預(yù)防的經(jīng)濟性和SARS-CoV-2的潛在影響。

213.Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways.

2002年人類癌癥的蛋白質(zhì)組學特征揭示了泛癌癥分子亞型和相關(guān)途徑。

214.Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ.

通過PPARδ重塑腫瘤免疫微環(huán)境快速加速KRAS突變型胰腺癌的發(fā)生。

215.Structural identification of vasodilator binding sites on the SUR2 subunit.

SUR2亞基上血管擴張劑結(jié)合點的結(jié)構(gòu)鑒定。

216.Phase separation and zinc-induced transition modulate synaptic distribution and association of autism-linked CTTNBP2 and SHANK3.

相分離和鋅誘導(dǎo)轉(zhuǎn)變調(diào)節(jié)自閉癥相關(guān)的CTTNBP2和SHANK3的突觸分布和關(guān)聯(lián)。

217.Mechanical instability generated by Myosin 19 contributes to mitochondria cristae architecture and OXPHOS.

由肌球蛋白19產(chǎn)生的機械不穩(wěn)定性有助于線粒體嵴結(jié)構(gòu)和OXPHOS。

218.Nuclear oligo hashing improves differential analysis of single-cell RNA-seq.

核寡頭散列改善了單細胞RNA-seq的差異化分析。

219.N6-methyladenosine regulated FGFR4 attenuates ferroptotic cell death in recalcitrant HER2-positive breast cancer.

N6-甲基腺苷調(diào)節(jié)的FGFR4減弱了頑固性HER2陽性乳腺癌的鐵質(zhì)細胞死亡。

220.Modulating gene regulation function by chemically controlled transcription factor clustering.

通過化學控制轉(zhuǎn)錄因子聚類來調(diào)節(jié)基因調(diào)控功能。

221.Regulation of the evolutionarily conserved muscle myofibrillar matrix by cell type dependent and independent mechanisms.

細胞類型依賴和獨立機制對進化保守的肌肉肌纖維基質(zhì)的調(diào)節(jié)。

222.Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant.

用滅活疫苗進行異源免疫，然后用mRNA增效劑引起對SARS-CoV-2 Omicron變體的強免疫力。

223.MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets.

MYC通過破壞雄性激素受體靶點的轉(zhuǎn)錄暫停釋放來驅(qū)動侵略性前列腺癌。

224.Quadrivalent mosaic HexaPro-bearing nanoparticle vaccine protects against infection of SARS-CoV-2 variants.

四價馬賽克HexaPro-bearing納米顆粒疫苗可防止SARS-CoV-2變體的感染。

225.On the origins of conductive pulse sensing inside a nanopore.

論納米孔內(nèi)導(dǎo)電脈沖感應(yīng)的起源。

226.Cryo-EM structure of human glucose transporter GLUT4.

人類葡萄糖轉(zhuǎn)運體GLUT4的低溫EM結(jié)構(gòu)。

227.Testing the adaptive hypothesis of lagging-strand encoding in bacterial genomes.

測試細菌基因組中滯后鏈編碼的適應(yīng)性假說。

228.Variant calling from scRNA-seq data allows the assessment of cellular identity in patient-derived cell lines.

從scRNA-seq數(shù)據(jù)中調(diào)用變體，可以評估患者衍生的細胞系的細胞身份。

229.Reply to: Testing the adaptive hypothesis of lagging-strand encoding in bacterial genomes.

回復(fù)：測試細菌基因組中滯后鏈編碼的適應(yīng)性假說。

230.Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells.

Runx1和Runx2抑制了造血干細胞的細胞龕的纖維化轉(zhuǎn)換。

231.In vitro reconstitution of Escherichia coli divisome activation.

大腸桿菌分裂體激活的體外重組。

232.Structural basis of ion – substrate coupling in the Na+-dependent dicarboxylate transporter VcINDY.

Na+依賴性二羧酸鹽轉(zhuǎn)運體VcINDY中離子-底物偶聯(lián)的結(jié)構(gòu)基礎(chǔ)。

233.Molecular basis for inhibiting human glucose transporters by exofacial inhibitors.

外源性抑制劑抑制人類葡萄糖轉(zhuǎn)運體的分子基礎(chǔ)。

234.Genomic diversity across the Rickettsia and ‘Candidatus Megaira’ genera and proposal of genus status for the Torix group.

Rickettsia和 "Candidatus Megaira "屬的基因組多樣性以及Torix組的屬地位建議。

235.Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans.

Neuroligin介導(dǎo)的神經(jīng)發(fā)育缺陷由線粒體功能障礙誘發(fā)，并由葉黃素在C. elegans中預(yù)防。

236.Large differences in carbohydrate degradation and transport potential among lichen fungal symbionts.

地衣真菌共生體之間碳水化合物降解和運輸潛力的巨大差異。

237.Reconstruct high-resolution 3D genome structures for diverse cell-types using FLAMINGO.

利用FLAMINGO重建不同細胞類型的高分辨率三維基因組結(jié)構(gòu)。

238.Active conformation of the p97-p47 unfoldase complex.

p97-p47解折疊酶復(fù)合物的活性構(gòu)象。

239.Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins.

腔內(nèi)壓力的機械加載通過調(diào)節(jié)F-BAR蛋白的TOCA家族來介導(dǎo)傷口血管生成。

240.MRNIP condensates promote DNA double-strand break sensing and end resection.

MRNIP凝集物促進DNA雙鏈斷裂感應(yīng)和末端切除。

241.Diurnal changes in the efficiency of information transmission at a sensory synapse.

感官突觸處信息傳輸效率的晝夜變化。

242.Ketamine activates adult-born immature granule neurons to rapidly alleviate depression-like behaviors in mice.

氯胺酮激活了成年出生的未成熟顆粒神經(jīng)元，迅速緩解了小鼠的抑郁癥樣行為。

243.Benchmarking of analysis strategies for data-independent acquisition proteomics using a large-scale dataset comprising inter-patient heterogeneity.

利用包含患者間異質(zhì)性的大規(guī)模數(shù)據(jù)集對數(shù)據(jù)無關(guān)的采集蛋白組學分析策略進行基準測試。

244.Characterization of RNA content in individual phase-separated coacervate microdroplets.

單個相分離的共析微滴中RNA含量的特征。

245.Signal transduction in light-oxygen-voltage receptors lacking the active-site glutamine.

缺少活性位點谷氨酰胺的光氧電壓受體的信號轉(zhuǎn)導(dǎo)。

246.Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex.

NALCN-FAM155A-UNC79-UNC80通道復(fù)合物的結(jié)構(gòu)和機制。

247.Arabidopsis cryptochrome 2 forms photobodies with TCP22 under blue light and regulates the circadian clock.

擬南芥隱色體2在藍光下與TCP22形成光體并調(diào)控晝夜節(jié)律。

248.Molecular insights into biogenesis of glycosylphosphatidylinositol anchor proteins.

對糖基磷脂酰肌醇錨定蛋白的生物生成的分子見解。

249.Substrate recognition and cryo-EM structure of the ribosome-bound TAC toxin of Mycobacterium tuberculosis.

結(jié)核分枝桿菌核糖體結(jié)合的TAC毒素的底物識別和低溫EM結(jié)構(gòu)。

250.Dissociable multi-scale patterns of development in personalized brain networks.

個人化大腦網(wǎng)絡(luò)中可分離的多尺度發(fā)展模式。

251.Sensory adaptation mediates efficient and unambiguous encoding of natural stimuli by vestibular thalamocortical pathways.

感覺適應(yīng)介導(dǎo)前庭丘腦皮層通路對自然刺激進行有效和明確的編碼。

252.Genome editing in animals with minimal PAM CRISPR-Cas9 enzymes.

具有最小PAM CRISPR-Cas9酶的動物的基因組編輯。

253.Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia.

線粒體復(fù)合體I的種系突變揭示了IDH1突變的急性骨髓性白血病的遺傳和靶向脆弱性。

254.Selective plasticity of callosal neurons in the adult contralesional cortex following murine traumatic brain injury.

小鼠腦外傷后成人對側(cè)皮質(zhì)胼胝體神經(jīng)元的選擇性可塑性。

255.CDK12 promotes tumorigenesis but induces vulnerability to therapies inhibiting folate one-carbon metabolism in breast cancer.

CDK12促進腫瘤發(fā)生，但誘導(dǎo)乳腺癌對抑制葉酸一碳代謝的療法的脆弱性。

256.Multimodal CEA-targeted fluorescence and radioguided cytoreductive surgery for peritoneal metastases of colorectal origin.

多模式CEA靶向熒光和放射引導(dǎo)下的結(jié)直腸腹膜轉(zhuǎn)移的細胞修復(fù)手術(shù)。

257.Dual-resolving of positional and geometric isomers of C=C bonds via bifunctional photocycloaddition-photoisomerization reaction system.

通過雙功能光合作用-光合作用異構(gòu)化反應(yīng)體系對C=C鍵的位置和幾何異構(gòu)體進行雙重解析。

258.Deep learning of a bacterial and archaeal universal language of life enables transfer learning and illuminates microbial dark matter.

細菌和古生物通用生命語言的深度學習實現(xiàn)了轉(zhuǎn)移學習并照亮了微生物暗物質(zhì)。

259.Gasdermin-A3 pore formation propagates along variable pathways.

Gasdermin-A3孔隙的形成沿可變路徑傳播。

260.Unlocking the functional potential of polyploid yeasts.

釋放多倍體酵母的功能潛力。

261.A rare variant analysis framework using public genotype summary counts to prioritize disease-predisposition genes.

使用公共基因型摘要計數(shù)的罕見變異體分析框架，以確定疾病傾向基因的優(yōu)先次序。

262.Immunoprofiling reveals cell subsets associated with the trajectory of cytomegalovirus reactivation post stem cell transplantation.

免疫分析揭示了與干細胞移植后巨細胞病毒反應(yīng)軌跡相關(guān)的細胞亞群。

263.TMEM16 scramblases thin the membrane to enable lipid scrambling.

TMEM16擾動器使膜變薄，從而實現(xiàn)了脂質(zhì)擾動。

264.3D chromatin remodelling in the germ line modulates genome evolutionary plasticity.

生殖線中的三維染色質(zhì)重塑調(diào)節(jié)基因組的進化可塑性。

265.Social isolation modulates appetite and avoidance behavior via a common oxytocinergic circuit in larval zebrafish.

社會隔離通過幼年斑馬魚的共同催產(chǎn)素回路調(diào)節(jié)食欲和回避行為。

266.PERSIST platform provides programmable RNA regulation using CRISPR endoRNases.

PERSIST平臺利用CRISPR內(nèi)切酶提供可編程的RNA調(diào)控。

267.Genetic analyses identify pleiotropy and causality for blood proteins and highlight Wnt/β-catenin signalling in migraine.

遺傳分析確定了血液蛋白的多態(tài)性和因果關(guān)系，并強調(diào)Wnt/β-catenin信號在偏頭痛中的作用。

268.Possible stochastic sex determination in Bursaphelenchus nematodes.

布爾遜線蟲可能的隨機性別決定。

269.Agrobacterium expressing a type III secretion system delivers Pseudomonas effectors into plant cells to enhance transformation.

表達III型分泌系統(tǒng)的農(nóng)桿菌將假單胞菌效應(yīng)物送入植物細胞以加強轉(zhuǎn)化。

270.Metabolite trafficking enables membrane-impermeable-terpene secretion by yeast.

代謝物販運使酵母的膜滲透性萜類物質(zhì)分泌成為可能。

271.Off-the-shelf CAR natural killer cells secreting IL-15 target spike in treating COVID-19.

現(xiàn)成的CAR自然殺傷細胞分泌IL-15靶向秒殺治療COVID-19。

272.Translaminar recurrence from layer 5 suppresses superficial cortical layers.

來自第5層的平移復(fù)發(fā)抑制了淺層皮質(zhì)層。

273.AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis.

AIMP2-DX2為控制KRAS驅(qū)動的腫瘤發(fā)生提供治療接口。

274.Discovery and characterization of a terpene biosynthetic pathway featuring a norbornene-forming Diels-Alderase.

以降冰片形成的Diels-Alderase為特征的萜類生物合成途徑的發(fā)現(xiàn)和特征分析。

275.Activation of Xist by an evolutionarily conserved function of KDM5C demethylase.

KDM5C去甲基化酶的進化保守功能對Xist的激活。

276.Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits.

撒哈拉以南非洲研究的Meta分析提供了對脂質(zhì)性狀遺傳結(jié)構(gòu)的見解。

277.Thioesters provide a plausible prebiotic path to proto-peptides.

硫酸鹽為原生肽提供了一個合理的前生物途徑。

278.Activity-induced polar patterns of filaments gliding on a sphere.

在球體上滑行的絲狀物的活動誘導(dǎo)極性模式。

279.Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients.

關(guān)于COVID-19門診患者療養(yǎng)血漿的兩項隨機試驗的前瞻性個體患者數(shù)據(jù)元分析。

280.Systematic and quantitative view of the antiviral arsenal of prokaryotes.

原核生物的抗病毒武器庫的系統(tǒng)和定量觀點。

281.Cumulative SARS-CoV-2 mutations and corresponding changes in immunity in an immunocompromised patient indicate viral evolution within the host.

累積的SARS-CoV-2突變和一個免疫力低下的病人免疫力的相應(yīng)變化表明病毒在宿主體內(nèi)的進化。

282.The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites.

G-蛋白偶聯(lián)受體的口袋組揭示了以前未被瞄準的異生位點。

283.EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation.

EZH2通過整合素β1-FAK的激活參與TGFβ信號的傳遞，促進乳腺癌骨轉(zhuǎn)移。

284.Environmental cues from neural crest derivatives act as metastatic triggers in an embryonic neuroblastoma model.

神經(jīng)嵴衍生物的環(huán)境線索在胚胎神經(jīng)母細胞瘤模型中充當轉(zhuǎn)移的觸發(fā)器。

285.Statin therapy inhibits fatty acid synthase via dynamic protein modifications.

他汀類藥物治療通過動態(tài)蛋白修飾抑制脂肪酸合成酶。

286.Profiling of hMPV F-specific antibodies isolated from human memory B cells.

從人類記憶B細胞中分離出的hMPV F特異性抗體的分析。

287.Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer.

長讀測序揭示了高分辨率HPV整合及其在宮頸癌中的致癌進展。

288.A genome-wide CRISPR-Cas9 knockout screen identifies essential and growth-restricting genes in human trophoblast stem cells.

全基因組CRISPR-Cas9基因敲除篩選發(fā)現(xiàn)人類滋養(yǎng)細胞干細胞中的重要和限制生長的基因。

289.Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection.

作為SARS-CoV-2感染的有效抑制劑的多價9-O-乙?；劝彼崽谴?。

290.Systematic review and meta-analysis of the effectiveness and perinatal outcomes of COVID-19 vaccination in pregnancy.

懷孕期間接種COVID-19疫苗的有效性和圍產(chǎn)期結(jié)果的系統(tǒng)回顧和薈萃分析。

291.A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease.

微生物組網(wǎng)絡(luò)對非酒精性脂肪肝患者運動和飲食干預(yù)的反應(yīng)的隨機對照試驗。

292.Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic.

來自歐洲的存檔流感病毒基因組揭示了1918年大流行期間的基因組變異性。

293.Serum metabolome associated with severity of acute traumatic brain injury.

與急性創(chuàng)傷性腦損傷嚴重程度有關(guān)的血清代謝組。

294.Identification of oleoylethanolamide as an endogenous ligand for HIF-3α.

鑒定油酰乙醇酰胺為HIF-3α的內(nèi)源性配體。

295.Plasma membrane phosphatidylinositol (4,5)-bisphosphate is critical for determination of epithelial characteristics.

血漿膜磷脂酰肌醇（4,5）-二磷酸對確定上皮特征至關(guān)重要。

296.Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors.

ATP位點和異生型EGFR抑制劑合作結(jié)合和協(xié)同作用的分子基礎(chǔ)。

297.Spatial epitranscriptomics reveals A-to-I editome specific to cancer stem cell microniches.

空間表征組學揭示了癌癥干細胞微循環(huán)特有的A-I編輯組。

298.A negative-solvatochromic fluorescent probe for visualizing intracellular distributions of fatty acid metabolites.

一種負溶于水的熒光探針用于觀察細胞內(nèi)脂肪酸代謝物的分布。

299.Double-tap gene drive uses iterative genome targeting to help overcome resistance alleles.

雙擊基因驅(qū)動使用迭代基因組靶向，幫助克服抗性等位基因。

300.The evolution of trait variance creates a tension between species diversity and functional diversity.

性狀變異的進化造成了物種多樣性和功能多樣性之間的矛盾。

301.Modulating the evolutionary trajectory of tolerance using antibiotics with different metabolic dependencies.

利用具有不同代謝依賴性的抗生素調(diào)控耐受性的進化軌跡。

302.Targeting double-strand break indel byproducts with secondary guide RNAs improves Cas9 HDR-mediated genome editing efficiencies.

用二級導(dǎo)引RNA靶向雙鏈斷裂吲哚副產(chǎn)物提高Cas9 HDR介導(dǎo)的基因組編輯效率。

303.Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate.

腸道微生物群通過丁酸鹽介導(dǎo)的腸道屏障功能的改變來調(diào)節(jié)急性骨髓性白血病。

304.Contribution of rare whole-genome sequencing variants to plasma protein levels and the missing heritability.

罕見全基因組測序變體對血漿蛋白水平的貢獻及缺失的遺傳性。

305.Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex.

人類跨模式皮層結(jié)構(gòu)和功能的遺傳和系統(tǒng)發(fā)育解耦。

306.Caveolin-1 temporal modulation enhances antibody drug efficacy in heterogeneous gastric cancer.

Caveolin-1的時間調(diào)控增強了異質(zhì)性胃癌的抗體藥物療效。

307.Culling corallivores improves short-term coral recovery under bleaching scenarios.

捕殺珊瑚動物可改善白化情況下的短期珊瑚恢復(fù)。

308.SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters.

SARS-CoV-2感染誘發(fā)金色敘利亞倉鼠的炎癥性骨質(zhì)流失。

309.Stress-induced protein disaggregation in the endoplasmic reticulum catalysed by BiP.

BiP催化的內(nèi)質(zhì)網(wǎng)中壓力誘導(dǎo)的蛋白質(zhì)分解。

310.Ataluren binds to multiple protein synthesis apparatus sites and competitively inhibits release factor-dependent termination.

Ataluren與多個蛋白質(zhì)合成器位點結(jié)合并競爭性地抑制釋放因子依賴的終止。

311.Distinctive molecular features of regenerative stem cells in the damaged male germline.

受損男性生殖系統(tǒng)中再生干細胞的獨特分子特征。

312.Calcium bursts allow rapid reorganization of EFhD2/Swip-1 cross-linked actin networks in epithelial wound closure.

鈣突發(fā)使上皮細胞傷口閉合過程中EFhD2/Swip-1交聯(lián)的肌動蛋白網(wǎng)絡(luò)快速重組。

313.SIMILE enables alignment of tandem mass spectra with statistical significance.

SIMILE使串聯(lián)質(zhì)譜的排列具有統(tǒng)計學意義。

314.An instantly fixable and self-adaptive scaffold for skull regeneration by autologous stem cell recruitment and angiogenesis.

一種通過自體干細胞招募和血管生成實現(xiàn)顱骨再生的即時固定和自適應(yīng)支架。

315.Neural signals regulating motor synchronization in the primate deep cerebellar nuclei.

調(diào)節(jié)靈長類小腦深部核團運動同步的神經(jīng)信號。

316.Structure of the Arabidopsis guard cell anion channel SLAC1 suggests activation mechanism by phosphorylation.

擬南芥守護細胞陰離子通道SLAC1的結(jié)構(gòu)表明磷酸化的激活機制。

317.Competition contributes to both warm and cool range edges.

競爭有助于暖區(qū)和冷區(qū)邊緣的形成。

318.A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury.

損傷后生長板軟骨再生需要FoxA2+長期干細胞群。

319.Preventing erosion of X-chromosome inactivation in human embryonic stem cells.

防止人類胚胎干細胞中X染色體失活的侵蝕。

320.Rationally engineering santalene synthase to readjust the component ratio of sandalwood oil.

合理設(shè)計檀香烯合成酶，重新調(diào)整檀香油的成分比例。

321.Genetic diversity of SARS-CoV-2 infections in Ghana from 2020-2021.

2020-2021年加納SARS-CoV-2感染的遺傳多樣性。

322.WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour.

在果蠅的雄性求偶行為中，WAKE通過層次分明的神經(jīng)內(nèi)分泌軸對cVA感知的調(diào)節(jié)。

323.Cryo-EM structures of thylakoid-located voltage-dependent chloride channel VCCN1.

位于葡萄球體的電壓依賴性氯離子通道VCCN1的低溫電鏡結(jié)構(gòu)。

324.Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer.

調(diào)節(jié)IRE1α依賴性衰變（RIDD）介導(dǎo)的癌癥中脂質(zhì)代謝的重新編程。

325.Stable inheritance of H3.3-containing nucleosomes during mitotic cell divisions.

有絲分裂細胞分裂過程中含H3.3的核糖體的穩(wěn)定繼承。

326.Protective effect of platinum nano-antioxidant and nitric oxide against hepatic ischemia-reperfusion injury.

鉑金納米抗氧化劑和一氧化氮對肝臟缺血再灌注損傷的保護作用。

327.Regulation of A-to-I RNA editing and stop codon recoding to control selenoprotein expression during skeletal myogenesis.

調(diào)節(jié)A-I RNA編輯和終止密碼子重編碼以控制骨骼肌生成過程中硒蛋白的表達。

328.Dandelion pappus morphing is actuated by radially patterned material swelling.

蒲公英蛹的形態(tài)是由徑向圖案的材料膨脹驅(qū)動的。

329.Fibronectin binding protein B binds to loricrin and promotes corneocyte adhesion by Staphylococcus aureus.

纖連蛋白結(jié)合蛋白B與Loricrin結(jié)合，促進金黃色葡萄球菌的角質(zhì)細胞粘附。

330.Transmembrane stem cell factor protein therapeutics enhance revascularization in ischemia without mast cell activation.

跨膜干細胞因子蛋白治療劑在不激活肥大細胞的情況下增強缺血時的血管再通。

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