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艾美捷SCREEN-WELL生物活性脂質(zhì)庫解決方案

2023-06-26 15:59 作者:艾美捷  | 我要投稿

SCREEN-WELL生物活性脂質(zhì)庫包含?190?種?96?孔格式的生物活性脂質(zhì)。非常適合篩選或鑒定重組孤兒?G?蛋白偶聯(lián)受體、靶標驗證、二次篩選、驗證新測定和常規(guī)藥理學(xué)應(yīng)用。

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The SCREEN-WELL? Bioactive Lipid Library contains 190 bioactive lipids in a 96 well format. Ideal for screening or identifiying recombinant orphan G protein-coupled receptors, target validation, secondary screening, validating new assays and for routine pharmacological applications.

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Applications:?HTS

Contents:?190 compounds including: Agonists & Antagonists, Endocannabinoids, Farnesyl/geranylgeranyl derivates, HETEs deHETEs, hepoxilins, Polyunsaturated fatty acids, Leukotrienes, lipoxins, LPA & phosphatidic acids, Octadecanoids, PAFs, Prostaglandins & thromboxanes, Retinoids, vitamin D metabolites, Sphingolipids.

Quantity:?100 or 500μl per well.

Concentration:?DMSO solutions (1.0 or 0.1mM, depending on compound).

Use/Stability:?Stable for at least one year from the date of receipt when stored at -80°C.

Long Term Storage:?-80°C

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艾美捷SCREEN-WELL生物活性脂質(zhì)庫#BML-2800-0100相關(guān)參數(shù)說明:

內(nèi)容:?190種化合物,包括:激動劑和拮抗劑,內(nèi)源性大麻素,法呢基/香葉基香葉基衍生物,HETEs deHETEs,七氧西林,多不飽和脂肪酸,白三烯,脂氧素,LPA和磷脂酸,十八烷類,PAF,前列腺素和血栓素,類維生素A,維生素D代謝物,鞘脂。

數(shù)量:?每孔100或500μl。

濃度:?DMSO溶液(1.0或0.1mM,取決于化合物)。

使用/穩(wěn)定性:在-80°C下儲存時,自收到之日起至少可穩(wěn)定一年。

航運:?干冰

長期儲存:-80°C

RUO -?僅供研究使用

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SCREEN-WELL生物活性脂質(zhì)庫部分文獻參考:

1.Molecular basis for the interaction of cellular retinol-binding protein 2 (CRBP2) with non-retinoid ligands: J. Silvaroli, et al.; J. Lipid Res. 62, 100054 (2021),

2.Mechanism of activation for the sirtuin 6 protein deacylase: M.A. Klein, et al.; J. Biol. Chem. 295, 1385 (2020),

3.Abnormal cannabidiol modulates vitamin A metabolism by acting as a competitive inhibitor of CRBP1: J.A. Silvaroli, et al.; ACS Chem. Biol. 14, 434 (2019),

4.Brown Adipogenic Reprogramming Induced by a Small Molecule: B. Nie, et al.; Cell Rep. 18, 624 (2017),

5.Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma: U.I. Scholl, et al.; J. Clin. Invest. 127, 2739 (2017),

6.AM251 Suppresses Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells: T. Yoshinaga, et al.; PLoS One 11, e0167848 (2016),

7.Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells: J.H. Rhim, et al.; Sci. Rep. 6, 26547 (2016),

8.Synthetic Ligands of Cannabinoid Receptors Affect Dauer Formation in the Nematode Caenorhabditis elegans: P.R. Rodrigues, et al.; G3 (Bethesda) 6, 1695 (2016),


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