關(guān)鍵詞

檢查點(diǎn)抑制劑?微生物群 巨噬細(xì)胞 免疫 托珠單抗 益生菌 單克隆抗體 雙特異性抗體

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#今日行業(yè)熱點(diǎn)#

①Science：Failed cancer therapy revived as powerful tumor killer when combined with newer drugs

血管生成抑制劑和檢查點(diǎn)抑制劑聯(lián)合使用可延遲肝細(xì)胞癌（HCC）復(fù)發(fā)

DOI:?10.1126/science.adi7665

②eBioMedicine：New evidence for the role of gut microbiota on atrial fibrillation development

腸道微生物群組成的改變和腸道微生物代謝的中斷與心血管疾病（CVD）的發(fā)生相關(guān)

DOI:?10.1016/j.ebiom.2023.104622

③ACS Nano：Bioengineered Nanospores Selectively Blocking LC3-Associated Phagocytosis in Tumor-Associated Macrophages Potentiate Antitumor Immunity

新型靶向TAM的Nanospores（PC-CW）選擇性阻斷腫瘤相關(guān)巨噬細(xì)胞中l(wèi)c3相關(guān)吞噬增強(qiáng)抗腫瘤免疫

DOI: 10.1021/acsnano.3c02657

④Current Opinion in Plant Biology ：Molecular engineering of plant immune receptors for tailored crop disease resistance

富含亮氨酸重復(fù)序列域受體(NLRs)的分子工程在植物免疫和抗病中的應(yīng)用

DOI: 10.1016/j.pbi.2023.102381

⑤Immunology & Cell Biology：Tocilizumab increases regulatory T cells, reduces natural killer cells and delays graft-versus-host disease development in humanized mice treated with post-transplant cyclophosphamide

托珠單抗(Tocilizumab, TOC)聯(lián)合環(huán)磷酰胺(post-transplant cyclophosphamide, PTCy)對人源化小鼠免疫細(xì)胞植入及移植物抗宿主病(GVHD)的影響

DOI: 10.1111/imcb.12652

⑥Probiotics and Antimicrobial Proteins：Immunomodulatory Activity of Probiotics in Models of Bacterial Infections

益生菌在細(xì)菌感染模型中的免疫調(diào)節(jié)活性

DOI: 10.1007/s12602-023-10090-6

⑦人源化抗硬骨素單克隆抗體候選藥物Blosozumab用于骨密度降低的中國區(qū)I期臨床實(shí)驗(yàn)獲得積極數(shù)據(jù)

⑧選擇性鞘氨醇-1-磷酸（S1P）受體調(diào)節(jié)劑Etrasimod用于中重度活動(dòng)性潰瘍性結(jié)腸炎（UC）的亞洲國際多中心Ⅲ期臨床試驗(yàn)已完成患者招募

⑨靶向CEACAM5 (CEA)和CD3的雙特異性抗體BA1202已獲得國家藥品監(jiān)督管理局藥品審評中心批準(zhǔn)開展用于實(shí)體瘤方向的臨床試驗(yàn)

⑩高效、高選擇性的小分子CDK7抑制劑TY-2699a獲國家藥品監(jiān)督管理局藥品審評中心（CDE）開展臨床試驗(yàn)批準(zhǔn)

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